Risk of gastric cancer in asymptomatic, middle-aged Japanese subjects based on serum pepsinogen and Helicobacter pylori antibody levels
Risk of gastric cancer in asymptomatic, middle-aged Japanese subjects based on serum pepsinogen and Helicobacter pylori antibody levels
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DOI：
10.1002/ijc.23571
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发表时间：
2008-08-15
影响因子：
6.4
通讯作者：
Ichinose, Masao
中科院分区：
文献类型：
--
作者：
Yanaoka, Kimihiko;Oka, Masashi;Ichinose, Masao
对5，209名无症状的中年受试者进行了为期10年的随访，这些受试者的血清胃蛋白酶原（PG）和幽门螺杆菌抗体水平已被评估。血清H. pylori抗体（> 50 U/mL）增加患癌风险（HR = 3.48，95% CI = 1.26-9.64）。胃癌的危险性随着抗体水平的升高而增加;抗体水平> 500 U/mL的幽门螺杆菌阳性组发病率最高（325/10万人年）。随着血清PG I水平的降低或PG I/II比值的降低，癌症的发生也增加;随着血清PG I水平的升高，
A total of 5,209 asymptomatic, middle-aged subjects, whose serum pepsinogen (PG) and Helicobacter pylori antibody levels had been assessed, were followed for 10 years. Subjects with positive serum H. pylori antibodies (> 50 U/mL) bad an increased cancer risk (HR = 3.48, 95% CI = 1.26-9.64). Risk of gastric cancer increased as the antibody level increased; the H. pylori-positive group with antibody levels > 500 U/mL had the highest incidence rate (325/100,000 person-years). Cancer development also increased with a reduced serum PG I level or a reduced PG I/II ratio; the risk was significantly elevated with serum PG I level