Sarcomatoid neoplasms of the respiratory tract.
Sarcomatoid neoplasms of the respiratory tract.
复制标题
呼吸道肉瘤样肿瘤。
DOI：
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发表时间：
1993
影响因子：
2.3
通讯作者：
M. Wick
中科院分区：
文献类型：
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作者：
O. Nappi;M. Wick
呼吸道类肉瘤（SCAs）是一种罕见的成人肿瘤，其中大多数是中年晚期的男性，他们有长期的烟草使用史。这些肿瘤可在鼻窦、鼻子、鼻口咽部、喉部、气管、中央支气管或周围肺实质中观察到。它们可能呈息肉样结构，向腔隙内投射，或表现为浸润性生长模式，与典型的高级别癌相似。组织学上，sca的双相和单相变异都是公认的。前者包括病灶为显性癌并伴有分化分化的间质组织，这类病变过去通常被称为“癌肉瘤”。另一方面，光镜下单相SCAs缺乏明显的上皮灶。超微结构和免疫组织学研究支持SCA代表了一个包括癌肉瘤和梭状细胞癌的连续体的概念，所有这些基本上都是上皮性肿瘤。肿瘤行为是位点依赖的；鼻、鼻窦、咽部和肺部的SCAs通常具有侵袭性病程，而喉部组织学上类似的病变通常在早期发现，因此预后较好。
Sarcomatoid carcinomas (SCAs) of the respiratory tract are uncommon neoplasms of adults, most of whom are men in late middle-age who have a long history of tobacco usage. These tumors may be observed in the paranasal sinuses, nose, naso-oropharynx, larynx, trachea, central bronchi, or peripheral lung parenchyma. They may assume a polypoid configuration, with projection into luminal spaces, or show an infiltrative growth pattern like that of typical high-grade carcinoma. Histologically, both biphasic and monophasic variants of SCAs are recognized. The former include tumors with foci of overt carcinoma admixed with areas of divergent differentiation into "committed" mesenchymal tissues, such lesions have usually been termed "carcinosarcomas" in the past. On the other hand, monophasic SCAs lack obviously epithelial foci on light microscopy. Ultrastructural and immunohistological studies support the notion that SCA represents a continuum that embraces carcinosarcomas and spindle-cell carcinomas, all of which are basically epithelial neoplasms. Tumor behavior is site-dependent; SCAs of the nose, sinuses, pharynx, and lungs usually pursue an aggressive course, whereas histologically similar lesions in the larynx are usually found at an earlier stage and, therefore, are associated with a better prognosis.