Hydroxytyrosol and Cytoprotection: A Projection for Clinical Interventions.
Hydroxytyrosol and Cytoprotection: A Projection for Clinical Interventions.
复制标题
DOI：
10.3390/ijms18050930
复制
发表时间：
2017-04-28
影响因子：
5.6
通讯作者：
Videla LA
中科院分区：
文献类型：
--
作者：
Echeverría F;Ortiz M;Valenzuela R;Videla LA
羟基酪醇(3，4-二羟基苯基)乙醇是一种多酚，主要存在于特级初榨橄榄油(EVOO)中，但也存在于红葡萄酒中。它具有强大的抗氧化作用，与供氢有关，并有能力提高自由基的稳定性。由于多种因素(种植地点、气候、橄榄品种和收获时的成熟程度)，橄榄油中的酚类含量在100至600毫克/公斤之间变化，羟色胺及其衍生物提供了一半的含量。当食用时，EVOO的酚类化合物在胃和肠道中被水解，增加游离羟色胺的水平，然后被小肠吸收，形成第二相代谢物。已经证明，即使在高剂量下服用羟色胺也是安全的，而且在体外没有遗传毒性或诱变性。羟色胺的有益影响已经在人类以及细胞和动物模型中进行了研究，主要与EVOO的消费有关。这种多酚除了具有抗氧化能力外，还具有许多特性。本综述的目的是评估羟色胺对人类健康的主要特性，重点是与可能预防和/或治疗非传染性疾病有关的特性。
Hydroxytyrosol (HT) ((3,4-Dihydroxyphenyl)ethanol) is a polyphenol mainly present in extra virgin olive oil (EVOO) but also in red wine. It has a potent antioxidant effect related to hydrogen donation, and the ability to improve radical stability. The phenolic content of olive oil varies between 100 and 600 mg/kg, due to multiple factors (place of cultivation, climate, variety of the olive and level of ripening at the time of harvest), with HT and its derivatives providing half of that content. When consumed, EVOO’s phenolic compounds are hydrolyzed in the stomach and intestine, increasing levels of free HT which is then absorbed in the small intestine, forming phase II metabolites. It has been demonstrated that HT consumption is safe even at high doses, and that is not genotoxic or mutagenic in vitro. The beneficial effects of HT have been studied in humans, as well as cellular and animal models, mostly in relation to consumption of EVOO. Many properties, besides its antioxidant capacity, have been attributed to this polyphenol. The aim of this review was to assess the main properties of HT for human health with emphasis on those related to the possible prevention and/or treatment of non-communicable diseases.