Methotrexate, Cyclosporine A, and Biologics Protect against Atherosclerosis in Rheumatoid Arthritis.
Methotrexate, Cyclosporine A, and Biologics Protect against Atherosclerosis in Rheumatoid Arthritis.
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DOI：
10.1155/2015/759610
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发表时间：
2015
影响因子：
4.1
通讯作者：
Tłustochowicz W
中科院分区：
文献类型：
--
作者：
Kisiel B;Kruszewski R;Juszkiewicz A;Raczkiewicz A;Bachta A;Tłustochowicz M;Staniszewska-Varga J;Kłos K;Duda K;Bogusławska-Walecka R;Płoski R;Tłustochowicz W
介绍。类风湿性关节炎（RA）的心血管疾病风险增加。一项荟萃分析显示RA患者的内膜中膜厚度（IMT）增加。研究表明，疾病调节抗风湿药物（DMARDs）可能影响动脉粥样硬化的进展。然而，有人认为生物制剂在预防动脉粥样硬化方面可能比其他dmard（包括甲氨蝶呤-甲氨蝶呤）更有效。目标。本研究的目的是评估不同RA特征和治疗方案对IMT和动脉粥样硬化斑块的影响。患者和方法：317例RA患者和111例对照纳入研究。测量颈动脉（CIMT）和股动脉（fitt）的IMT。检查动脉是否有斑块。结果。接受甲氨蝶呤(MTX)≥20mg /周、环孢素（CsA）或生物制剂治疗的患者的CIMT、FIMT和斑块患病率低于接受低剂量MTX和其他疾病改善抗风湿药物治疗的患者。使用MTX≥20mg /周、生物制剂或CsA治疗的患者的IMT没有差异。结论。我们发现MTX≥20mg /周、生物制剂和CsA对动脉粥样硬化有有益作用。我们没有证实生物制剂对IMT的影响比MTX治疗剂量更大。
Introduction. The risk of cardiovascular disease is increased in rheumatoid arthritis (RA). A meta-analysis showed increased intima media thickness (IMT) in RA. It has been shown that disease modifying antirheumatic drugs (DMARDs) may influence the progression of atherosclerosis. However, it was suggested that biologics may be more efficient than other DMARDs (including methotrexate—MTX) in protecting against atherosclerosis. Objectives. The aim of this study was to assess the influence of different RA characteristics and treatment regimens on IMT and atherosclerotic plaques. Patients and Methods. 317 RA patients and 111 controls were included in the study. IMT was measured in carotid (CIMT) and femoral (FIMT) arteries. Arteries were screened for the presence of plaques. Results. CIMT, FIMT, and prevalence of plaques were lower in patients treated with methotrexate (MTX) ≥ 20 mg/wk, cyclosporine (CsA), or biologics than in patients treated with lower doses of MTX and other disease modifying antirheumatic drugs. No differences in IMT between patients treated with MTX ≥ 20 mg/wk, biologics, or CsA were found. Conclusions. We found a beneficial effect of MTX ≥ 20 mg/wk, biologics, and CsA on atherosclerosis. We do not confirm a stronger influence of biologics on IMT compared with therapeutic doses of MTX.
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影响因子：
105.7
作者：
Danesh, J;Whincup, P;Pepys, MB
通讯作者：
Pepys, MB
影响因子：
3.2
作者：
Angel, Kristin;Provan, Sella A.;Atar, Dan
通讯作者：
Atar, Dan
影响因子：
--
作者：
del Rincón, I;Williams, K;Escalante, A
通讯作者：
Escalante, A
影响因子：
--
作者：
Dixon, W G;Watson, K D;Lunt, M;Hyrich, K L;Silman, A J;Symmons, D P M
通讯作者：
Symmons, D P M
DOI：
10.1093/rheumatology/keu224
发表时间：
2014-12
期刊：
Rheumatology (Oxford, England)
影响因子：
--
作者：
Choy E;Ganeshalingam K;Semb AG;Szekanecz Z;Nurmohamed M
通讯作者：
Nurmohamed M