Transsphenoidal hypophysectomy in the clinically normal dog.
Transsphenoidal hypophysectomy in the clinically normal dog.
复制标题
临床正常犬的经蝶垂体切除术。
DOI：
10.1080/10889370109377709
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发表时间：
1988
影响因子：
1
通讯作者：
G. Bottoms
中科院分区：
文献类型：
--
作者：
G. Lantz;S. Ihle;R. Nelson;W. Carlton;E. Feldman;C. D. Lothrop;G. Bottoms
研究临床正常犬经蝶窦垂体切除术后垂体功能及短期临床效果。在研究1中，8只狗在手术后的头12小时内给予IV型多离子液体。在研究II中，4只狗给予多离子液体IV和糖皮质激素补充7天。垂体功能的评估方法包括垂体切除术前、1周和12周生长激素刺激试验、垂体切除术前、1周、4周、8周和12周促甲状腺激素释放激素刺激试验、垂体切除术前、1周、4周、8周和12周改良缺水/抗利尿激素反应试验。术后12周对手术部位、甲状腺、肾上腺和皮肤进行大体和组织学评估。研究1中的四只狗在垂体切除术后的27小时内死亡。这些狗的死后检查显示肝和肺充血与循环衰竭相一致。研究二中没有一只狗死亡。在这两项研究中幸存的狗，尿崩症在垂体切除术后立即发生，并在2周内消退。垂体切除术后也立即出现高钠血症，并在1周内消退。在垂体切除术后1周和12周，所有狗的ACTH产生明显，手术后ACTH刺激试验结果与术前结果无显著差异。促甲状腺激素释放激素刺激和生长激素刺激试验结果支持垂体切除术引起的甲状腺功能减退和促生长功能减退的诊断。组织学检查显示，所有狗的甲状腺萎缩、表皮和真皮萎缩、肾上腺正常，研究一中2只狗的垂体残余。
Pituitary function and short-term clinical effects after transsphenoidal hypophysectomy were investigated in clinically normal dogs. In study I, 8 dogs were given polyionic fluids IV during the first 12 hours after surgery. In study II, 4 dogs were given polyionic fluids IV and glucocorticoid supplementation for 7 days. Pituitary function was assessed by evaluating basal ACTH concentrations and results of a growth hormone stimulation test before and 1 and 12 weeks after hypophysectomy, an ACTH stimulation test, a thyrotropin-releasing hormone-stimulation test, and a modified water deprivation/vasopressin response test before and 1, 4, 8, and 12 weeks after hypophysectomy. Gross and histologic evaluations of the surgery site, thyroid and adrenal glands, and skin were done at 12 weeks after surgery. Four dogs from study I died within 27 hours after hypophysectomy. Postmortem examinations of these dogs revealed liver and lung congestion compatible with circulatory collapse. None of the dogs in study II died. For the surviving dogs in both studies, diabetes insipidus developed immediately after hypophysectomy and resolved within 2 weeks. Hypernatremia also developed immediately after hypophysectomy and resolved by 1 week. Production of ACTH was evident at 1 and 12 weeks after hypophysectomy in all dogs, and results of ACTH stimulation tests after surgery were not notably different from results obtained before surgery. Results of thyrotropin-releasing hormone stimulation and growth hormone-stimulation tests supported the diagnosis of hypothyroidism and hyposomatotropism attributable to hypophysectomy. Histologic examination revealed thyroid atrophy, epidermal and dermal atrophy, and normal adrenal glands in all dogs and remnants of the hypophysis in 2 dogs from study I.(ABSTRACT TRUNCATED AT 250 WORDS)