Antiparasitic activities of bimetallic N‐heterocyclic carbene gold(I) complexes with ferrocene ligands: relevance of chlorido and phosphino ligands
Antiparasitic activities of bimetallic N‐heterocyclic carbene gold(I) complexes with ferrocene ligands: relevance of chlorido and phosphino ligands
复制标题
双金属Nâ杂环卡宾金(I)与二茂铁配体配合物的抗寄生虫活性：氯代和膦基配体的相关性
DOI：
10.1002/aoc.6952
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发表时间：
2022
影响因子：
3.9
通讯作者：
Biersack B.
中科院分区：
文献类型：
--
作者：
Al Nasr I.S;Weise M;Koko W.S;Khan T.A;Schobert R;Biersack B.
制备了含咪唑-2-亚基配体和二茂铁取代基的金（I）配合物。测定了它们对利什曼原虫和弓形虫的体外活性。某些金（I）与氯和1，1 ′-双（三苯基膦基）二茂铁配体的配合物显示出良好的抗寄生虫作用。新的氯代配合物5和5c显示出对弓形虫和主要前鞭毛体的高活性，而新的二茂铁桥连的双金（I）配合物8a和8b对主要前鞭毛体特别有活性，并且对于来自Vero细胞和巨噬细胞的毒性结果具有相当大的选择性。
Gold(I) complexes carrying imidazole‐2‐ylidene ligands and ferrocene substituents were prepared. Their activities against protozoalLeishmania majorandToxoplasma gondiiparasites were analyzed. Certain gold(I) complexes with chlorido and 1,1′‐bis(triphenylphosphino)ferrocene ligands revealed promising antiparasitic effects. The new chlorido complexes5band5cshowed high activities againstT. gondiitachyzoites andL. majorpromastigotes while the new ferrocene‐bridged bis‐gold(I) complexes8aand8bwere particularly active againstL. majoramastigotes and considerably selective as to toxicity results from Vero cells and macrophages.