Removing the cloak of invisibility: phenotyping the mouse
Removing the cloak of invisibility: phenotyping the mouse
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DOI：
10.1242/dmm.001057
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发表时间：
2008-09-01
影响因子：
4.3
通讯作者：
Justice, Monica J.
中科院分区：
文献类型：
--
作者：
Justice, Monica J.
如果您研究人类疾病，您可能会尝试生成小鼠模型。有时，这些模型非常出色；有时，这些模型非常出色。其他人则令人失望。或者，我们是这么认为的。由于我们看待疾病的方式的限制，我们的小鼠突变体有多少次无法模拟人类疾病？在任何生物体中，许多因素共同作用产生表型。在这里，描述并提出了用于评估小鼠生物学和生理学的新表型范式。小鼠表型评估的进展与人类临床诊断相似。未来会出现多种可能暴露于各种条件的小鼠品系。要评估健康状况，需要能够对每只动物进行广泛的表型评估，直到我们能够了解一个系统的扰动如何影响其他系统。
If you study a human disease, it is likely that you have tried to generate a mouse model. Sometimes, these models are excellent; others are disappointing. Or, so we think. How often does our mouse mutant not model the human disease because of limitations in how we may look at it? In any living organism, many factors work together to produce the phenotype. Here, new phenotyping paradigms for assessing mouse biology and physiology are described and proposed. Advances in mouse phenotype assessments have paralleled human clinical diagnostics. The future brings a multitude of mouse strains that might be exposed to a variety of conditions. To assess health will require the ability to perform a broad-based phenotype assessment of every animal until we can understand how the perturbation of one system affects others.