Hyperthermia: an effective strategy to induce apoptosis in cancer cells
Hyperthermia: an effective strategy to induce apoptosis in cancer cells
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DOI：
10.1007/s10495-015-1168-3
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发表时间：
2015-11-01
期刊：
影响因子：
7.2
通讯作者：
Kondo, Takashi
中科院分区：
文献类型：
--
作者：
Ahmed, Kanwal;Tabuchi, Yoshiaki;Kondo, Takashi
在整个人类历史上，热一直被用作一种医学和治疗方式。热疗联合放疗和抗癌药物已在临床上得到应用，并取得了一定的效果。然而，单独HT治疗的临床结果仅部分令人满意。HT处理后的细胞死亡是温度和处理持续时间的函数。HT通过凋亡诱导癌细胞死亡;凋亡的程度和凋亡途径在不同的癌细胞类型中不同。HT诱导的活性氧产生负责各种细胞类型的凋亡。然而，信号转导的潜在机制和与此过程相关的基因仍然需要阐明。本文就HT诱导细胞凋亡的分子机制、热诱导细胞凋亡的增强作用以及HT诱导细胞凋亡的遗传网络进行综述。
Heat has been used as a medicinal and healing modality throughout human history. The combination of hyperthermia (HT) with radiation and anticancer agents has been used clinically and has shown positive results to a certain extent. However, the clinical results of HT treatment alone have been only partially satisfactory. Cell death following HT treatment is a function of both temperature and treatment duration. HT induces cancer cell death through apoptosis; the degree of apoptosis and the apoptotic pathway vary in different cancer cell types. HT-induced reactive oxygen species production are responsible for apoptosis in various cell types. However, the underlying mechanism of signal transduction and the genes related to this process still need to be elucidated. In this review, we summarize the molecular mechanism of apoptosis induced by HT, enhancement of heat-induced apoptosis, and the genetic network involved in HT-induced apoptosis.