Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas.
Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas.
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在人卵泡淋巴瘤中检测第二t（14; 18）断点簇区域。
DOI：
10.1084/jem.164.1.315
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发表时间：
1986-07-01
影响因子：
15.3
通讯作者：
Sklar, J
中科院分区：
文献类型：
--
作者：
Cleary, M L;Galili, N;Sklar, J
我们的研究结果表明，有两个主要的断裂点簇区域的18号染色体DNA的t（14;18）易位在滤泡性淋巴瘤。在含有pFL-2可检测易位的细胞系中pFL-1同源转录物的缺失表明t（14;18）易位可能有两种不同的致病后果。一种可能性是，尽管它们之间的距离（大于20 kb），但两个簇区域中的断点以某种方式影响相同基因产物的转录，这尚未被确定。或者，可能涉及两个单独的转录单位。两个t（14;18）断裂点簇区域的DNA探针的可用性将允许进一步研究这两类遗传上不同的t（14;18）易位的生物学意义。
Our results indicate that there are two major breakpoint cluster regions in chromosome 18 DNA for t(14;18) translocations in follicular lymphomas. The absence of a pFL-1 homologous transcript in a cell line containing a pFL-2-detectable translocation suggests that there may be two different pathogenetic consequences of t(14;18) translocations. One possibility is that, despite the distances between them (greater than 20 kb), breakpoints in the two cluster regions in some way affect transcription of the same gene product, which has not yet been identified. Alternatively, two separate transcriptional units may be involved. The availability of DNA probes for each of the two t(14;18) breakpoint cluster regions will allow further studies regarding the biologic significance of these two genetically distinct classes of t(14;18) translocations.