Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla
Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla
复制标题
铁木栎树皮多酚提取物的降血糖和基因毒性作用评价
DOI：
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发表时间：
2016
影响因子：
--
通讯作者：
N. Paniagua
中科院分区：
文献类型：
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作者：
M. Soto;M. Rosales;G. Escalona;N. Paniagua
Quercus sideroxyla is a wood species whose bark has phenolic compound and should be considered to be bioactive; the hypoglycemic and genotoxic properties of Q. sideroxyla bark were evaluated in this study. Total phenolic compound was determined in crude extract (CE) and organic extract (OE). The OE has the highest amount of phenols (724.1 ± 12.0 GAE/g). Besides, both CE and OE demonstrated effect over the inhibition of α-amylase in vitro. Hypoglycemic activity was assessed by glucose tolerance curve and the area under curve (UAC); OE showed the highest hypoglycemic activity. In addition, diabetes was induced by streptozotocin (65 mg/kg) and the extracts (50 mg/kg) were administered for 10 days; OE showed hypoglycemic effect compared with diabetic control and decreased hepatic lipid peroxidation. Acute toxicity and genotoxicity were evaluated in CE; results of acute toxicity did not show any mortality. Besides, the comet assay showed that CE at a dose of 100 mg/kg did not show any genotoxic effect when evaluated at 24 h, whereas it induced slight damage at 200 mg/kg, with the formation of type 1 comets.
DOI：
10.1016/j.bbadis.2014.10.006
发表时间：
2015-06
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
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作者：
Pasinetti, Giulio Maria;Wang, Jun;Ho, Lap;Zhao, Wei;Dubner, Lauren
通讯作者：
Dubner, Lauren