HEALTH-RELATED QUALITY OF LIFE IN CERVICAL CANCER SURVIVORS: A POPULATION-BASED SURVEY
HEALTH-RELATED QUALITY OF LIFE IN CERVICAL CANCER SURVIVORS: A POPULATION-BASED SURVEY
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DOI：
10.1016/j.ijrobp.2008.06.1905
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发表时间：
2009-04-01
影响因子：
7
通讯作者：
van Ballegooijen, Marjolein
中科院分区：
文献类型：
--
作者：
Korfage, Ida J.;Essink-Bot, Marie-Louise;van Ballegooijen, Marjolein
目的：在一个以人群为基础的宫颈癌幸存者样本中，对诊断后2-10年的健康相关生活质量(HRQOL)进行评估。方法和材料：所有1995-2003年在荷兰埃因霍温地区被诊断为宫颈癌的患者，以及2006年1月以后存活的患者都是通过癌症登记来确认的。我们评估了一般HRQOL(36个条目的简式健康调查，EQ-5D)、特定于宫颈癌的HRQL(欧洲研究与治疗组织或癌症生活质量问卷)和焦虑(6个条目的状态特质焦虑问卷)，并与参考人群(n=349)进行比较。结果：共有291名女性(69%)回答，平均年龄53+/-13岁(SD)(范围31-88岁)。治疗h：包括手术(n=195)或综合治疗(n=75)；1名妇女未接受治疗。在所有女性中，85%的人临床上没有疾病，2%的人有复发/转移，13%的人这一点是未知的。在控制了背景特征(年龄、教育程度、工作和婚姻状况、有孩子和出生国家)后，一般HRQOL量表得分与参考人群相似，但幸存者的心理健康状况较差。最常见的症状是腹部或腹部痉挛疼痛(17%)，尿漏(15%)，更年期症状(18%)，以及性活动问题。与6-10年的幸存者相比，2-5年的幸存者报告了更多的性焦虑和更差的身体形象。与单纯手术相比，尤其是初次放射治疗，在诊断和随访时控制了年龄和疾病阶段后，与治疗相关的副作用的发生率增加。结论：大多数宫颈癌幸存者的心理健康状况比参考人群差，但他们的应对能力很好。即使在2-10年后，放射治疗也与治疗相关副作用的频率增加有关。(C)2009年爱思唯尔公司。
Purpose: In a population-based sample of cervical cancer survivors, health-related quality of life (HRQoL) was assessed 2-10 years postdiagnosis.Methods and Materials: All patients given a diagnosis of cervical cancer in 1995-2003 in the Eindhoven region, The Netherlands, and alive after Jan 2006 were identified through the cancer registry. Generic HRQoL (36-Item Short-Form Health Survey, EQ-5D), cervical cancer-specific HRQoL (European Organization for Research and Treatment or Cancer Quality-of-Life questionnaire cervical cancer module), and anxiety (6-item State Trait Anxiety Inventory) were assessed and compared with a reference population (n = 349). Data for tumor characteristics at diagnosis and disease progression were available.Results: A total of 291 women responded (69%), with a mean age of 53 +/- 13 (SD) years (range, 31-88 years). Treatment h:id consisted of surgery (n = 195) or a combination of therapies (n = 75); one woman had not been treated. Of all women, 85% were clinically disease free, 2% had a recurrence/metastasis, and in 13%, this was unknown. After controlling for background characteristics (age, education, job and marital status, having children, and country of birth), generic HRQoL scale scores were similar to the reference population, except for worse mental health in survivors. The most frequent symptoms were crampy pain in the abdomen or belly (17%), urinary leakage (15%), menopausal symptoms (18%), and problems with sexual activity. Compared with the 6-10-year survivors, more sexual worry and worse body image were reported by the 2-5-year survivors. Compared with surgery only, especially primary radiotherapy was associated with an increased frequency of treatment-related side effects, also after controlling for age and disease stage at diagnosis and follow-up.Conclusions: Most cervical cancer survivors were coping well, although their mental health was worse than in the reference population. Even after 2-10 years, radiotherapy was associated with an increased frequency of treatment-related side effects. (C) 2009 Elsevier Inc.