Learning-dependent Changes in the Neuronal Correlates of Response Inhibition in the Prefrontal Cortex and Hippocampus.
Learning-dependent Changes in the Neuronal Correlates of Response Inhibition in the Prefrontal Cortex and Hippocampus.
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DOI：
10.5607/en.2014.23.2.178
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发表时间：
2014-06
影响因子：
2.4
通讯作者：
Byeon JS
中科院分区：
文献类型：
--
作者：
Lee I;Byeon JS
研究表明，海马和前额叶皮层（PFC）在表征情境记忆和利用情境信息进行灵活的反应选择中起着关键作用。在反应选择过程中，正确的反应应该被促进，不正确的反应应该被灵活地抑制。然而，人们对海马和PFC网络在灵活控制行为反应的易化和抑制过程中的表现知之甚少。为了寻找情境线索柔性反应选择的神经相关因素，本研究采用了一个客体-位置配对联想（OPPA）任务，在该任务中，客体A仅在位置1被奖励，客体B在位置2与奖励相关联，同时记录海马和PFC的单个单位。在上下文错误的物体前的反应抑制是成功执行所必需的，并且在大鼠学习任务之前观察到这种抑制反应。一个显着比例的神经元，发射差异取决于抑制行为的存在，在PFC的预学习阶段观察。相反，在学习后阶段，这种神经元在海马中的比例显著大于机会。结果表明，抑制行为的发展是一个重要的行为标记，预示着任务的即将获得，海马和前额叶通过学习如何控制行为的抑制来参与学习情境反应的选择。
It has been suggested that the hippocampus and the prefrontal cortex (PFC) play key roles in representing contextual memory and utilizing contextual information for flexible response selection. During response selection, a correct response should be facilitated and an incorrect response should be inhibited flexibly in association with a cueing stimulus. However, it is poorly understood how the hippocampal and PFC networks behave during such flexible control of facilitation and inhibition of behavioral responses. To find neural correlates of context-cued flexible response selection, the current study employed an object-place paired-associate (OPPA) task in which object A is only rewarded in place 1 and object B is associated with reward in place 2 while recording single units simultaneously from the hippocampus and PFC. During the task, response inhibition in front of a contextually wrong object is required for successful performance and such inhibitory responses were observed before the rat learned the task. A significant proportion of neurons that fired differentially depending on the existence of inhibitory behavior in the PFC was observed during the pre-learning stage. By contrast, the proportion of such neurons in the hippocampus was significantly greater than chance during post-learning stage. The results suggest that the development of inhibitory behavior is a critical behavioral marker that foretells an upcoming acquisition of the task and the hippocampus and PFC are involved in learning contextual response selection by learning how to control the inhibition of behavior as learning progresses.