Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in paired maternal and neonatal samples from South China: Placental transfer and potential risks
Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in paired maternal and neonatal samples from South China: Placental transfer and potential risks
复制标题
中国南方配对母婴样本中的羟基多溴二苯醚 (OH-PBDE)：胎盘转移和潜在风险
DOI：
10.1016/j.envres.2016.03.021
复制
发表时间：
2016-07-01
影响因子：
8.3
通讯作者：
Wang, Hong-Sheng
中科院分区：
文献类型：
--
作者：
Chen, Zhuo-Jia;Liu, Han-Yan;Wang, Hong-Sheng
羟基化多溴联苯醚（OH-PBDEs）因其对神经发育的毒性作用而受到越来越多的关注。我们评估了从华南地区收集的30份母婴配对胎盘、母乳、胎儿脐带血和新生儿尿液样本中15种OH-PBDEs和3种溴苯酚（BRP）同类物的浓度。在胎盘、母乳和脐带血中，西格玛羟基多溴二苯醚的几何平均浓度分别为37.6、61.3和76.8皮克/克（-1）湿重。胎盘、母乳和脐带血中Sigma BRP的GM浓度分别为47.6、119和30.2 pg g（-1）ww。新生儿尿液中Sigma OH-PBDEs和EBRP的GM浓度分别为72.0和79.8 pg/ml。在所分析的15种羟基多溴二苯醚同系物中，最常检测到的三种同系物是2 '-OH-BDE-68（72.1%）、6-OH-BDE-47（67.6%）和2'-OH-BDE-28（65.8%）。母乳喂养婴儿的羟基多溴二苯醚估计日摄入量为9.31 +/- 4.00纳克/千克体重/天。羟基多溴二苯醚在新生儿体内的累积量远低于估计的神经毒性最低观察效应浓度。本研究首次提供了华南地区新生儿及其母亲接触羟基多溴联苯醚的系统基础数据。(C)2016 Elsevier Inc. All rights reserved.
Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are attracting more and more attention for the neurodevelopment toxicity effects. We evaluated the concentrations of 15 individual OH-PBDEs and 3 bromophenol (BRP) congeners in 30 mother-newborn paired placenta, breast milk, fetal cord blood, and neonatal urine samples collected from South China. The geometric mean (GM) concentrations of Sigma OH-PBDEs were 37.6, 61.3, and 76.8 pg g(-1) ww in placenta, breast milk, and cord blood, respectively. The GM concentrations of Sigma BRPs were 47.6, 119, and 30.2 pg g(-1) ww in placenta, breast milk, and cord blood, respectively. The GM concentrations of Sigma OH-PBDEs and EBRPs in neonatal urine were 72.0 and 79.8 pg ml(-1), respectively. Of the 15 OH-PBDE congeners analyzed, the three most frequently detected congeners were 2'-OH-BDE-68 (72.1%), 6-OH-BDE-47 (67.6%), and 2'-OH-BDE-28 (65.8%). The estimated daily intake (EDI) of OH-PBDEs for the breast-fed infants was 9.31 +/- 4.00 ng kg(-1) bw day. The accumulation of OH-PBDEs in newborns was much lower than the estimated lowest observed-effect concentration (LOEC) of neurotoxicity. The present study provided the first systematic fundamental data that exposure to OH-PBDEs for newborn and their mothers in South China. (C) 2016 Elsevier Inc. All rights reserved.