Fabrication of Encapsulated Ag Microsphere with Hydroxyapatite for Sustained-Release

Fabrication of Encapsulated Ag Microsphere with Hydroxyapatite for Sustained-Release
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DOI：
10.4028/www.scientific.net/kem.361-363.1199
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发表时间：
2007-11
期刊：
Key Engineering Materials
影响因子：
--
通讯作者：
Takeshi Yabutsuka;S. Tsuboi;M. Hibino;T. Yao
Takeshi Yabutsuka;S. Tsuboi;M. Hibino;T. Yao
中科院分区：
其他
文献类型：
--
作者：
Takeshi Yabutsuka;S. Tsuboi;M. Hibino;T. Yao

文献摘要

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通过提高模拟体液(SBF)的pH值合成了磷灰石晶核。磷灰石晶核附着在银微球表面。从磷灰石核中诱导出羟基磷灰石(HAP)，并在SBF中分散到银微球的整个表面积上，制备了包覆有羟基磷灰石的银微球。将含有羟基磷灰石的银微球浸泡在生理盐水中，测定了银离子在生理盐水中的浓度变化。羟基磷灰石包裹的银微球对银离子有缓释作用。
Apatite nuclei were synthesized by raising pH of simulated body fluid (SBF). The apatite nuclei were attached to surfaces of Ag microspheres. Hydroxyapatite (HAp) was induced from the apatite nuclei and spread over whole surface area of the Ag microspheres in SBF, then encapsulated Ag microspheres with HAp were fabricated. The encapsulated Ag microspheres with HAp were soaked in saline and changes in Ag ion concentration in saline were measured. The encapsulated Ag microspheres with HAp showed sustained-release of Ag ion.