Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study.
Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study.
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DOI：
10.1371/journal.pone.0147565
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Yoshida M
中科院分区：
文献类型：
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作者：
Teraguchi M;Yoshimura N;Hashizume H;Muraki S;Yamada H;Oka H;Minamide A;Ishimoto Y;Nagata K;Kagotani R;Tanaka S;Kawaguchi H;Nakamura K;Akune T;Yoshida M
本研究的目的是检查代谢综合征（MS）的组成部分，如超重（OW），高血压（HT），血脂异常（DL），糖耐量受损（IGT）和椎间盘退变（DD）之间的关系。本研究包括和歌山脊柱研究的1,011名参与者中的928名参与者（308名男性，620名女性）。根据Pfirrmann系统对磁共振成像上的DD进行分类。使用日本MS标准审查委员会的标准评估OW、HT、DL和IGT。多变量逻辑回归分析显示，OW与颈椎、胸椎和腰椎DD显著相关（颈椎：比值比[OR]，1.28; 95%置信区间[CI]，0.92-1.78;胸椎：OR，1.75; 95% CI，1.24-2.51;腰椎：OR，1.87; 95% CI，1.06-3.48）。HT和IGT与胸DD显著相关（HT：OR，1.54; 95%CI，1.09-2.18; IGT：OR，1.65; 95%CI，1.12-2.48）。此外，有1个或多个MS组分的受试者的胸DD OR高于无MS组分的受试者（与无组分相比; 1个组分：OR，1.58; 95% CI，1.03-2.42; 2个组分：OR，2.60; 95% CI，1.62-4.20; ≥3个组分：OR，2.62; 95% CI，1.42-5.00）。MS组分与胸DD显著相关。此外，MS组分的蓄积显著增加了胸DD的OR。这些发现支持需要进一步研究代谢异常对DD的影响。
The objective of the present study was to examine the associations between metabolic syndrome (MS) components, such as overweight (OW), hypertension (HT), dyslipidemia (DL), and impaired glucose tolerance (IGT), and intervertebral disc degeneration (DD). The present study included 928 participants (308 men, 620 women) of the 1,011 participants in the Wakayama Spine Study. DD on magnetic resonance imaging was classified according to the Pfirrmann system. OW, HT, DL, and IGT were assessed using the criteria of the Examination Committee of Criteria for MS in Japan. Multivariable logistic regression analysis revealed that OW was significantly associated with cervical, thoracic, and lumbar DD (cervical: odds ratio [OR], 1.28; 95% confidence interval [CI], 0.92–1.78; thoracic: OR, 1.75; 95% CI, 1.24–2.51; lumbar: OR, 1.87; 95% CI, 1.06–3.48). HT and IGT were significantly associated with thoracic DD (HT: OR, 1.54; 95% CI, 1.09–2.18; IGT: OR, 1.65; 95% CI, 1.12–2.48). Furthermore, subjects with 1 or more MS components had a higher OR for thoracic DD compared with those without MS components (vs. no component; 1 component: OR, 1.58; 95% CI, 1.03–2.42; 2 components: OR, 2.60; 95% CI, 1.62–4.20; ≥3 components: OR, 2.62; 95% CI, 1.42–5.00). MS components were significantly associated with thoracic DD. Furthermore, accumulation of MS components significantly increased the OR for thoracic DD. These findings support the need for further studies of the effects of metabolic abnormality on DD.