INFLUENCE OF HEPATOCELLULAR CARCINOMA ETIOLOGY IN THE SURVIVAL AFTER RESECTION.
INFLUENCE OF HEPATOCELLULAR CARCINOMA ETIOLOGY IN THE SURVIVAL AFTER RESECTION.
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DOI：
10.1590/0102-6720201600020010
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
Herman P
中科院分区：
文献类型：
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作者：
Lopes Fde L;Coelho FF;Kruger JA;Fonseca GM;Araujo RL;Jeismann VB;Herman P
肝细胞癌（Hepatocellular carcinoma，HCC）是最常见的原发性肝癌，近几十年来其发病率在世界范围内呈上升趋势，已成为世界上第三大癌症死亡原因。肝切除术是HCC最有效的治疗方法之一，5年生存率为50- 70%，特别是对于单个结节和保留肝功能的患者。一些研究表明，肝细胞癌患者的病因是病毒的预后较差。这就给我们带来了一个问题，即HCC的各种病因及其预后之间存在差异。 比较接受肝切除术治疗HCC的患者在各种肝病原因方面的预后（5年时的总体和无病生存率）。 对2000年至2014年期间接受肝切除术治疗HCC的患者的病历进行了审查。他们根据肝病的原因分组，然后进行总体和无病生存分析进行比较。 根据HCC病因分组的患者结局无统计学显著差异。该样本中患者的5年总体生存率和无病生存率分别为49.9%和40.7%。 从该样本的数据中，证实了各种病因的HCC患者组之间没有预后差异。
Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and its incidence is increasing around the world in the last decades, making it the third cause of death by cancer in the world. Hepatic resection is one of the most effective treatments for HCC with five-year survival rates from 50-70%, especially for patients with a single nodule and preserved liver function. Some studies have shown a worse prognosis for HCC patients whose etiology is viral. That brings us to the question about the existence of a difference between the various causes of HCC and its prognosis. To compare the prognosis (overall and disease-free survival at five years) of patients undergoing hepatectomy for the treatment of HCC with respect to various causes of liver disease. Was performed a review of medical records of patients undergoing hepatectomy between 2000 and 2014 for the treatment of HCC. They were divided into groups according to the cause of liver disease, followed by overall and disease-free survival analysis for comparison. There was no statistically significant difference in the outcomes of the groups of patients divided according to the etiology of HCC. Overall and disease-free survival at five years of the patients in this sample were 49.9% and 40.7%, respectively. From the data of this sample, was verified that there was no prognostic differences among the groups of HCC patients of the various etiologies.