Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition
Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition
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DOI：
10.1016/j.canlet.2012.05.024
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发表时间：
2012-12-01
期刊：
影响因子：
9.7
通讯作者：
Maciaczyk, Jaroslaw
中科院分区：
文献类型：
--
作者：
Kahlert, Ulf D.;Maciaczyk, Donata;Maciaczyk, Jaroslaw
在这里，我们发现经典WNT/β-连环蛋白通路的激活增加了干细胞基因的表达，并促进了胶质母细胞瘤的迁移和侵袭能力。WNT信号的调节改变了上皮细胞向间充质细胞转化激活因子的表达，表明这一过程在调节胶质瘤motility.Using免疫组化在患者来源的胶质母细胞瘤样品中的作用，我们发现更多的细胞与β-连环蛋白的核内信号在肿瘤浸润边缘相比，中央肿瘤实质。这些发现表明，经典WNT/β-catenin途径是GBM侵袭的关键调节因子，并可能代表潜在的治疗靶点。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Here we show that activation of the canonical WNT/beta-catenin pathway increases the expression of stem cell genes and promotes the migratory and invasive capacity of glioblastoma. Modulation of WNT signaling alters the expression of epithelial-to-mesenchymal transition activators, suggesting a role of this process in the regulation of glioma motility.Using immunohistochemistry in patient-derived glioblastoma samples we showed higher numbers of cells with intranuclear signal for beta-catenin in the infiltrating edge of tumor compared to central tumor parenchyma. These findings suggest that canonical WNT/beta-catenin pathway is a critical regulator of GBM invasion and may represent a potential therapeutic target. (C) 2012 Elsevier Ireland Ltd. All rights reserved.