Impact of oxidative stress SNPs and dietary antioxidant quality score on prostate cancer
Impact of oxidative stress SNPs and dietary antioxidant quality score on prostate cancer
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DOI：
10.1080/09637486.2019.1680958
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发表时间：
2019-10-24
影响因子：
3.9
通讯作者：
Alvarez-Cubero, M. J.
中科院分区：
文献类型：
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作者：
Pascual-Geler, M.;Robles-Fernandez, I.;Alvarez-Cubero, M. J.
目的：分析西班牙人群中抗氧化基因型和饮食抗氧化质量评分（DAQ）对前列腺癌（PCa）风险和侵袭性的影响之间的关系。方法：PSA值>4 ng/ml的男性（N = 155例患者和152例对照）入选该项目。考虑到西班牙人的每日推荐摄入量（DRI），使用了DAQ。对5个SNPs rs662（PON 1）、rs 10432782（SOD 1）、rs 4880（SOD 2）、rs 17650792（GPX 1）和rs 1001179（CAT）进行基因分型。结果：rs 17650792在病例组和对照组之间差异有统计学意义。当比较D ' Amico风险时，我们发现rs662（CC）、rs 10432782（G等位基因）和rs 17650792（GG）赋予保护作用。当测试SNP-抗氧化营养素相互作用时，我们发现维生素A和rs 100179（T携带者）和硒和rs 17650792（G携带者）的摄入量可以保护处于低风险分类。结论：我们首次报道了rs662（PON 1）与PCa侵袭性之间的相关性。
Purpose: To analyse the relation between antioxidant genotypes and Dietary Antioxidant Quality score (DAQs) effect on prostate cancer (PCa) risk and aggressiveness in a Spanish population. Methods: Men (N = 155 patients and 152 controls) with PSA values >4 ng/ml were enrolled in the project. DAQs were used considering the daily recommended intake for Spanish people (DRI). Genotyping of 5 SNPs rs662 (PON1), rs10432782 (SOD1), rs4880 (SOD2), rs17650792 (GPX1) and rs1001179 (CAT) were included for the analysis. Results: rs17650792 was statistically significant between case and controls subjects. When comparing D ' Amico risk, we found that rs662 (CC), rs10432782 (G allele) and rs17650792 (GG) confer a protection. When testing SNP-antioxidant nutrients interactions, we found an intake of vitamin A and rs100179 (T carriers) and selenium and rs17650792 (G carriers) confers a protection of being in low risk classification. Conclusions: We reported by the first time a correlation between rs662 (PON1) and PCa aggressiveness.