Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway
Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway
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DOI：
10.1021/jacs.8b10904
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发表时间：
2019-04-17
影响因子：
15
通讯作者：
Yu, Chengzhong
中科院分区：
文献类型：
--
作者：
Gu, Zhengying;Liu, Tianqing;Yu, Chengzhong
氧化铁纳米颗粒（IONP）通过将肿瘤相关巨噬细胞从肿瘤促进表型（M2）极化为肿瘤抑制表型（M1）而具有新兴的抗癌应用。然而，其潜在的机制和结构-功能关系仍不清楚。我们报告磁铁矿IONP在M1极化和肿瘤抑制方面比赤铁矿更有效。此外，磁铁矿IONP特异性地依赖于干扰素调节因子5信号通路用于M1极化并下调M2相关的抑制酶-1。该研究为设计先进的铁基抗癌技术提供了新的认识和铺平了道路。
Iron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing phenotype (M1). However, the underlying mechanism and structure-function relationship remain unclear. We report magnetite IONPs are more effective compared to hematite in M1 polarization and tumor suppression. Moreover, magnetite IONPs specifically rely on interferon regulatory factor 5 signaling pathway for M1 polarization and down-regulate M2-assoicated arginase-1. This study provides new understandings and paves the way for designing advanced iron-based anticancer technologies.