SUMOylation in control of accurate chromosome segregation during mitosis.
SUMOylation in control of accurate chromosome segregation during mitosis.
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DOI：
10.2174/138920312802430563
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发表时间：
2012-08
影响因子：
2.8
通讯作者：
Zhang XD
中科院分区：
文献类型：
--
作者：
Wan J;Subramonian D;Zhang XD
小泛素相关修饰剂 (SUMO) 的翻译后蛋白修饰已成为有丝分裂过程中染色体分离的重要调节机制。本综述重点关注 SUMOylation 如何调节着丝粒和着丝粒活动，以在有丝分裂过程中实现准确的染色体分离。着丝粒组装在称为着丝粒的特殊染色质结构域上，并作为附着纺锤体微管以将姐妹染色单体与子细胞分离的位点。最近发现许多与有丝分裂着丝粒和着丝粒相关的蛋白质可以被 SUMO 修饰。尽管我们仍处于阐明 SUMOylation 如何控制有丝分裂过程中染色体分离的早期阶段，但在过去十年中已经取得了实质性进展。此外，最近有丝分裂中 SUMO 化的研究出现的一个主要主题是 SUMO 接合和解接合对于动粒组装和拆卸都至关重要。最后，我们提出了一个 SUMOylation 协调多个着丝粒和着丝粒活动的模型，以确保准确的染色体分离。
Posttranslational protein modification by small ubiquitin-related modifier (SUMO) has emerged as an important regulatory mechanism for chromosome segregation during mitosis. This review focuses on how SUMOylation regulates the centromere and kinetochore activities to achieve accurate chromosome segregation during mitosis. Kinetochores are assembled on the specialized chromatin domains called centromeres and serve as the sites for attaching spindle microtubule to segregate sister chromatids to daughter cells. Many proteins associated with mitotic centromeres and kinetochores have been recently found to be modified by SUMO. Although we are still at the early stage of elucidating how SUMOylation controls chromosome segregation during mitosis, a substantial progress has been achieved over the past decade. Furthermore, a major theme that has emerged from the recent studies of SUMOylation in mitosis is that both SUMO conjugation and deconjugation are critical for kinetochore assembly and disassembly. Lastly, we propose a model that SUMOylation coordinates multiple centromere and kinetochore activities to ensure accurate chromosome segregation.