Cytotoxic isoquinoline quinones from sponges of the genus Petrosia.
Cytotoxic isoquinoline quinones from sponges of the genus Petrosia.
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来自 Petrosia 海绵的细胞毒性异喹啉醌。
DOI：
10.1080/1057563031000122130
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Ireland,ChrisM
中科院分区：
文献类型：
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作者：
Sandoval,ImeldaT;Davis,RohanA;Bugni,TimS;Concepcion,GiselaP;Harper,MaryKay;Ireland,ChrisM
通过生物测定引导对两种菲律宾海绵进行分馏，分离出新型天然产物克布他汀 7 (1) 和已知化合物雷尼尔酮 (2) 和 O-去甲基雷尼尔酮 (3)。这些异喹啉醌的结构是通过光谱数据的解释确定的。化合物1、2和3对HCT 116人结肠癌细胞系具有细胞毒性，IC50值分别为45、24和34μg/mL。
Bioassay-guided fractionation of two Philippine sponges of the genusPetrosiahas resulted in the isolation of the novel natural product cribrostatin 7 (1) and the known compounds renierone (2) andO-demethylrenierone (3). The structures of these isoquinoline quinones were determined by interpretation of spectroscopic data. Compounds1,2and3were cytotoxic against the HCT 116 human colon carcinoma cell line with IC50values of 45, 24 and 34 µg/mL, respectively.