Fluid-attenuated inversion recovery MR imaging: Identification of protein concentration thresholds for CSF hyperintensity
Fluid-attenuated inversion recovery MR imaging: Identification of protein concentration thresholds for CSF hyperintensity
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DOI：
10.2214/ajr.169.3.9275912
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发表时间：
1997-09-01
影响因子：
5
通讯作者：
Eustace, S
中科院分区：
文献类型：
--
作者：
Melhem, ER;Jara, H;Eustace, S
目标。我们利用人体志愿者和模拟脑脊液的体模，分析了不同蛋白质浓度对生理盐水信号强度的影响。此外，对于不同的液体衰减反转恢复(FLAIR)序列，我们比较了来自这些溶液的信号变得高信号的蛋白质浓度阈值与来自脑实质的信号。9种不同浓度的白蛋白溶液(3.9 mg/dl至2500 mg/dl)在不同的有效TES(110、150、200和250毫秒)下使用快速FLAIR MR序列(TR6000毫秒；反转时间1730毫秒；回声串长度20)进行成像。五名健康志愿者的大脑使用相同的序列进行了成像。我们绘制了不同白蛋白溶液的信噪比与白蛋白浓度的曲线图，并与来自脑实质和CSF的平均信噪比进行了关联。结果我们看到来自白蛋白溶液的信噪比随着白蛋白浓度的增加而逐渐增加，随着有效TE的增加，曲线图与来自脑实质的平均信噪比的交点出现在较低的白蛋白浓度。结论：使用模体和健康志愿者，FLAIR磁共振成像可能有助于评估脑脊液蛋白质浓度增加的病理条件，我们定义了一个蛋白质浓度阈值，超过这个阈值，来自生理盐水的信号变得比来自脑实质的信号更强。该阈值取决于FLAIR序列中使用的有效TE，并且对于110毫秒的有效TE为250 mg/dl，对于150毫秒的有效TE为125 mg/dl，对于200毫秒的有效TE为110 mg/dl，对于250毫秒的有效TE为95 mg/dl。
OBJECTIVE. Using human volunteers and phantoms emulating CSF, we analyzed the effects of varying protein concentration on the signal intensity of saline solution. Also, for different fluid-attenuated inversion recovery (FLAIR) sequences, we compared protein concentration thresholds above which the signal from these solutions becomes hyperintense to that from brain parenchyma.SUBJECTS AND METHODS. Nine albumin solutions of varying concentrations (3.9 mg/dl to 2500 mg/dl) were imaged using fast FLAIR MR sequences (TR, 6000 msec; inversion time, 1730 msec; echo train length, 20) at different effective TEs (110, 150, 200, and 250 msec). The brains of five healthy volunteers were imaged using the same sequences. Plots of signal-to-noise ratios from the different albumin solutions versus albumin concentration were generated and correlated with average signal-to-noise ratios from brain parenchyma and CSF.RESULTS. We saw a gradual increase in signal-to-noise ratios from the albumin solutions as a function of albumin concentration, As the effective TE increased, the point of intersection between the plots and the average signal-to-noise ratio from brain parenchyma occurred at lower albumin concentrations.CONCLUSION. FLAIR MR imaging is potentially useful to evaluate pathologic conditions that increase CSF protein concentration, Using phantoms and healthy volunteers, we defined a protein concentration threshold above which the signal from saline solutions becomes hyperintense to that from brain parenchyma. This threshold depends on the effective TE used in the FLAIR sequence and is 250 mg/dl for an effective TE of 110 msec, 125 mg/dl for 150 msec, 110 mg/dl for 200 msec, and 95 mg/dl for 250 msec.