DETERMINATIONS OF ETHANOL, ACETALDEHYDE AND ACETATE IN BLOOD AND URINE DURING ALCOHOL OXIDATION IN MAN
DETERMINATIONS OF ETHANOL, ACETALDEHYDE AND ACETATE IN BLOOD AND URINE DURING ALCOHOL OXIDATION IN MAN
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DOI：
10.1093/oxfordjournals.alcalc.a044872
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发表时间：
1989-01-01
影响因子：
2.8
通讯作者：
TAINAKA, H
中科院分区：
文献类型：
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作者：
TSUKAMOTO, S;MUTO, T;TAINAKA, H
日本男性在 20 分钟内饮用 16 毫升/公斤的啤酒后，通过顶空气相色谱法分析了日本男性酒精氧化过程中血液和尿液样本中的乙醇、乙醛和乙酸盐。发现血液/尿液乙醇的最高水平为15-17 mM (20-22 mM)，而冲洗器和非冲洗器中乙醛的最高水平分别为20 μM (52 μM)和2-5 μM (10-13 μM)。这些组中的乙酸水平范围为 0.2 mM (0.1 mM) 至 0.8 mM (1.0 mM)。血液乙醇水平呈剂量依赖性，而乙醛和乙酸盐水平则反映个体代谢率。血液中乙醇和乙醛的相对浓度以及酒精代谢中乙酸盐的相对浓度可概括如下：7500(15mM)：1-3(2-5μM)；非冲洗器为 250-400 (0.5-0.8 mM)；对于冲洗器，7500 (15 mM): 5-10 (10-20 μM): 250-400 (0.5-0.8 mM)。
Blood and urine samples were analyzed for ethanol, acetaldehyde and acetate during alcohol oxidation in Japanese men by head space gas chromatography, following the consumption of 16 ml/kg of beer during a 20 min period. The maximum level of blood/urine ethanol was found to be 15-17 mM (20-22 mM), while that of acetaldehyde in a flusher and in non-flushers was 20 .mu.M (52 .mu.M) and 2-5 .mu.M (10-13 .mu.M), respectively. Acetate levels in these groups ranged from 0.2 mM (0.1 mM) to 0.8 mM (1.0 mM). Blood ethanol levels were dose dependent, whereas acetaldehyde and acetate levels reflected individual metabolic rates. The relative concentrations of ethanol and acetaldehyde in blood and that of acetate in alcohol metabolism could be summarized as follows: 7500 (15 mM): 1-3 (2-5 .mu.M); 250-400 (0.5-0.8 mM) for non-flushers; and 7500 (15 mM): 5-10 (10-20 .mu.M): 250-400 (0.5-0.8 mM) for a flusher.