Low doses of methylmercury intoxication solely or associated to ethanol binge drinking induce psychiatric-like disorders in adolescent female rats
Low doses of methylmercury intoxication solely or associated to ethanol binge drinking induce psychiatric-like disorders in adolescent female rats
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DOI：
10.1016/j.etap.2018.04.021
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发表时间：
2018-06-01
影响因子：
4.3
通讯作者：
Ferraz Maia, Cristiane Socorro
中科院分区：
文献类型：
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作者：
Almeida Belem-Filho, Ivaldo Jesus;Ribera, Paula Cardoso;Ferraz Maia, Cristiane Socorro
甲基汞 (MeHg) 是一种环境污染物，会对发育中的大脑造成损害。同时，青少年的乙醇消耗量有所增加。关于低剂量甲基汞本身或与青春期乙醇相关的影响的证据很少。因此，我们研究了青春期大鼠因接触低剂量甲基汞并与乙醇共中毒而导致的行为障碍。 Wistar 大鼠长期暴露于低剂量的甲基汞（40 微克/公斤/天，持续 5 周）和/或乙醇暴饮（3 克/公斤/天，每周 3 天，持续 5 周）。对动物进行行为分析以评估情绪和认知功能。评估了大脑和头发中的总汞含量。分析血液样本中的氧化参数。低剂量的甲基汞或与过量饮酒相关的甲基汞会产生类似精神疾病和认知障碍。在外围，甲基汞与乙醇结合时会改变氧化参数。乙醇注射减少了脑汞沉积。我们提出，乙醇降低了显示精神类疾病/认知障碍的汞组织水平的必要性。
Methylmercury (MeHg) is an environmental contaminant that provokes damage to developing brain, Simultaneously, the consumption of ethanol among adolescents has increased. Evidence concerning the effects of MeHg low doses per se or associated with ethanol during adolescence are scarce. Thus, we investigate behavioral disorders resulted from exposure to MeHg low doses and co-intoxicated with ethanol in adolescent rats. Wistar rats received chronic exposure to low doses of MeHg (40 sg/kg/day for 5 weeks) and/or ethanol binge drinking (3 g/kg/day at 3 days per week for 5 weeks). Animals were submitted to behavioral assays to assess emotionality and cognitive function. Total mercury content was evaluated in the brain and hair. Oxidative parameters were analyzed in blood samples. MeHg at low doses or associated to ethanol binge drinking produced psychiatric-like disorders and cognitive impairment. Peripherally, MeHg altered oxidative parameters when associated to ethanol. Ethanol administration reduced brain mercury deposit. We proposed that ethanol reduces the necessity of mercury tissue levels to display psychiatric-like disorders/cognitive impairment.