Complexity of subthalamic 13-35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease
Complexity of subthalamic 13-35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease
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DOI：
10.1016/j.expneurol.2010.03.015
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发表时间：
2010-07-01
影响因子：
5.3
通讯作者：
Brown, Peter
中科院分区：
文献类型：
--
作者：
Chen, Chiung Chu;Hsu, Yi Ting;Brown, Peter
基底神经节神经元在13- 35-Hz频带中的活动过度同步，即所谓的β活动，与帕金森病（PD）的运动缺陷有关。研究表明，多巴胺能药物治疗和丘脑底核高频刺激可抑制β活性，抑制程度与临床改善相关。然而，这些研究未能证明帕金森氏症在静息、未治疗状态下的β活性之间存在任何相关性。这与β活动和运动障碍之间的显著关系相矛盾。在这里，我们使用一个先进的非线性动力学分析方法的基础上Lempel-Ziv估计，以显示频带和特定的局部场电位（LFP）的复杂性和运动障碍的PD患者之间的相关性。振荡活动具有降低的复杂性，我们发现在13- 35-Hz频率范围内，运动不能-僵硬的复杂性之间存在很强的负相关性。与震颤没有这种相关性。此外，在0- 12-Hz频带上的LFP Lempel-Ziv复杂性（LZC）与任何帕金森病运动障碍之间没有相关性。结果加强了在β频段的同步（LFP）活动的动态结构之间的关联，在运动不能刚性。(C)2010年爱思唯尔公司All rights reserved.
Excessive synchronization of the basal ganglia neuronal activity in the 13- to 35-Hz frequency band, so-called beta activity, has been associated with the motor deficits of Parkinson's disease (PD). Studies have demonstrated that beta activity may be suppressed by treatment with dopaminergic medication and high-frequency stimulation of the subthalamic nucleus (STN), with the degree of suppression correlating with clinical improvement. However, these studies failed to demonstrate any correlation between beta activity of parkinsonism in the resting, untreated state. This argues against a significant relationship between beta activity and motor impairment. Here we use an advanced nonlinear dynamical analysis method based on the Lempel-Ziv estimator to show frequency band and symptom-subset specific correlations between STN local field potential (LFP) complexity and motor impairment in PD patients. Oscillatory activity has a reduced complexity, and we found a strong negative correlation between the complexity of the STN LFP over the 13- to 35-Hz frequency range and akinesia-rigidity. There was no such correlation with tremor. Furthermore, there was no correlation between LFP Lempel-Ziv complexity (LZC) over the 0- to 12-Hz frequency band and any parkinsonian motor impairment. The results strengthen the association between the dynamic structure of synchonised (LFP) activity in the beta frequency band in the STN and akinesia-rigidity. (C) 2010 Elsevier Inc. All rights reserved.