Highly Efficient Vacancy-Driven Photothermal Therapy Mediated by Ultrathin MnO2 Nanosheets
Highly Efficient Vacancy-Driven Photothermal Therapy Mediated by Ultrathin MnO2 Nanosheets
复制标题
超薄 MnO2 纳米片介导的高效空位驱动光热疗法
DOI：
10.1021/acsami.8b20639
复制
发表时间：
2019-02-13
影响因子：
9.5
通讯作者：
Zhou, Shuyun
中科院分区：
文献类型：
--
作者：
Wang, Li;Guan, Shanyue;Zhou, Shuyun
二维纳米材料具有良好的生物相容性、稳定性和多功能性，在医学应用中得到了广泛的研究。在此，已通过简单的水热工艺制备了MnO2纳米片。高光热转换性能（62.4%）可以归因于空位的xMnO2纳米片，如扩展的X射线吸收精细结构的结果和密度泛函理论计算所证实的，有利于光声成像引导的癌症治疗。这种高效的空位诱导光热疗法是首次报道。因此，这项工作表明，这种MnO2纳米片具有构建用于成像引导癌症治疗的纳米系统的潜力。
In medical applications, two-dimensional nanomaterials have been widely studied on account of their intriguing properties such as good biocompatibility, stability, and multifunctionality. Herein, an ultrathin MnO2 nanosheet has been fabricated by a simplistic hydrothermal process. The high photothermal conversion performance (62.4%) can be attributed to the vacancy in the ultrathin MnO, nanosheet, as confirmed by the extended Xray absorption fine structure results and the density functional theory calculation, benefiting photoacoustic imaging-guided cancer therapy. This highly efficient vacancy-induced photothermal therapy has been reported for the first time. As a result, this work demonstrates that this ultrathin MnO2 nanosheet has a potential to construct a nanosystem for imaging-guided cancer therapy.