Source localization of epileptic spikes using Multiple Sparse Priors.
Source localization of epileptic spikes using Multiple Sparse Priors.
复制标题
使用多稀疏先验的癫痫棘波源定位。
DOI：
10.1016/j.clinph.2020.10.030
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Tucker D
中科院分区：
文献类型：
--
作者：
Fernandez-Corazza M;Feng R;Ma C;Hu J;Pan L;Luu P;Tucker D
利用多重稀疏先验（MSP）反演方法和高分辨率的个体电头模型评估癫痫源估计。准确的电源定位依赖于准确的电头模型和适当的逆求解。使用15例癫痫患者的高分辨率个体脑电模型，以手术切除和临床结果为准确性标准，将MSP方法的性能与标准化低分辨率脑电磁断层扫描（sLORETA）和相干最大平均熵（cMEM）方法进行比较。MSP方法的成功率与sLORETA方法相似，略优于cMEM方法。与sLORETA相比，MSP和cMEM方法具有不需要任意选择超参数或重构电流密度值阈值来确定焦点的优点。在空间色散方面，MSP和cMEM方法优于sLORETA方法。结果表明，这三种方法是互补的，可以一起使用。在实践中，MSP方法比sLORETA更容易使用和解释，比cMEM方法更准确和更快。从密集阵列脑电图数据中定位间隔尖峰的来源已被证明是癫痫病灶的可靠标记，对术前计划有用。MSP的优点使其在临床实践中成为其他反求解器的有益补充。
To evaluate epileptic source estimation using multiple sparse priors (MSP) inverse method and high-resolution, individual electrical head models. Accurate source localization is dependent on accurate electrical head models and appropriate inverse solvers. Using high-resolution, individual electrical head models in fifteen epilepsy patients, with surgical resection and clinical outcome as criteria for accuracy, performance of MSP method was compared against standardized low-resolution brain electromagnetic tomography (sLORETA) and coherent maximum entropy on the mean (cMEM) methods. The MSP method performed similarly to the sLORETA method and slightly better than the cMEM method in terms of success rate. The MSP and cMEM methods were more focal than sLORETA with the advantage of not requiring an arbitrary selection of a hyperparameter or thresholding of reconstructed current density values to determine focus. MSP and cMEM methods were better than sLORETA in terms of spatial dispersion. Results suggest that the three methods are complementary and could be used together. In practice, the MSP method will be easier to use and interpret compared to sLORETA, and slightly more accurate and faster than the cMEM method. Source localization of interictal spikes from dense-array electroencephalography data has been shown to be a reliable marker of epileptic foci and useful for pre-surgical planning. The advantages of MSP make it a useful complement to other inverse solvers in clinical practice.
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