Bilateral symmetry and coherence of subthalamic nuclei beta band activity in Parkinson's disease
Bilateral symmetry and coherence of subthalamic nuclei beta band activity in Parkinson's disease
复制标题
DOI：
10.1016/j.expneurol.2009.11.012
复制
发表时间：
2010-01-01
影响因子：
5.3
通讯作者：
Bronte-Stewart, Helen
中科院分区：
文献类型：
--
作者：
de Solages, Camille;Hill, Bruce C.;Bronte-Stewart, Helen
在帕金森病(PD)中，基底节神经元活动的异常同步性与感觉运动回路的功能障碍有关。特别是，在贝塔范围内(13-35赫兹)的频率振荡由多巴胺能药物专门调节，并与受试者的临床状态相关。虽然这些振荡在帕金森病患者的同侧基底节内以及在基底节核团和同侧运动皮质之间是一致的，但它们的一致性的两侧程度从未被表征过。在这里，我们第一次证明，记录在丘脑底核(STN)局部场势中的β带振荡，虽然在不同的受试者之间看起来不同，但以相同的频率发生在两侧(p
Abnormal synchronization of neuronal activity in the basal ganglia has been associated with the dysfunction of sensorimotor circuits in Parkinson's disease (PD). In particular, oscillations at frequencies within the beta range (13-35 Hz) are specifically modulated by dopaminergic medication and are correlated with the clinical state of the subjects. While these oscillations have been shown to be coherent ipsilaterally within the basal ganglia and between the basal ganglia nuclei and the ipsilateral motor cortex in PD, the bilateral extent of their coherence has never been characterized. Here we demonstrate for the first time that the beta band oscillations recorded in the local field potential of the subthalamic nuclei (STN), while appearing different across subjects, are occurring at the same frequencies bilaterally (p