Genome of Bifidobacteria and Carbohydrate Metabolism.
Genome of Bifidobacteria and Carbohydrate Metabolism.
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双歧杆菌和碳水化合物代谢的基因组。
DOI：
10.5851/kosfa.2015.35.1.1
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发表时间：
2015
影响因子：
--
通讯作者：
Delcenserie V
中科院分区：
文献类型：
--
作者：
Bondue P;Delcenserie V
近年来，由于分子生物学的最新进展，有关双歧杆菌的知识有了很大的发展。双歧杆菌48个类群的全基因组序列分析为其分类提供了新的视角，特别是在两个物种之间建立界限。事实上，有几个物种表现出高度的同源性，应该重新分类。另一方面，一些亚种的同源性较低，因此应重新分类为不同的物种。此外，更好地了解双歧杆菌基因组可以更好地理解复杂碳水化合物代谢的机制。来自人类和动物来源的某些双歧杆菌物种的基因组表明，参与复杂寡糖代谢的基因大量存在。应进一步测试这些物种，以确认它们在体外和体内代谢复杂寡糖的潜力。
In recent years, the knowledge about bifidobacteria has considerably evolved thanks to recent progress in molecular biology. The analysis of the whole genome sequences of 48 taxa of bifidobacteria offers new perspectives for their classification, especially to set up limit between two species. Indeed, several species are presenting a high homology and should be reclassified. On the other hand, some subspecies are presenting a low homology and should therefore be reclassified into different species. In addition, a better knowledge of the genome of bifidobacteria allows a better understanding of the mechanisms involved in complex carbohydrate metabolism. The genome of some species of bifidobacteria from human but also from animal origin demonstrates high presence in genes involved in the metabolism of complex oligosaccharides. Those species should be further tested to confirm their potential to metabolize complex oligosaccharides in vitro and in vivo.