Concentrations of selective metabolites of organophosphorus pesticides in the United States population
Concentrations of selective metabolites of organophosphorus pesticides in the United States population
复制标题
DOI：
10.1016/j.envres.2005.03.012
复制
发表时间：
2005-11-01
影响因子：
8.3
通讯作者：
Needham, LL
中科院分区：
文献类型：
--
作者：
Barr, DB;Allen, R;Needham, LL
我们报告了毒死蜱(3，5，6-三氯-2-吡啶醇；TCPY)、甲基毒死蜱(TCPY)、马拉硫磷(马拉硫磷二元酸；丙二醛)、二氮磷(2-异丙基-4-甲基-6-羟基嘧啶；IMPY)、甲基对硫磷(对硝基苯酚；PNP)和对硫磷(PNP)选择性代谢物的基于人群的浓度(按年龄、性别和复合种族/民族变量分层)。我们测量了1999-2000年国家健康和营养检查调查参与者1997年尿样中TCPY、MDA、IMPY和PNP的浓度。我们在超过96%的测试样本中检测到了TCPY。其他有机磷农药代谢物的检出频率较低：丙二醛，52%；咪唑，29%；对苯二酚，22%。TCPY的几何均数分别为1.77mUg/L和1.58mUg/g肌酐。TCPY的第95个百分位数分别为9.9mU/g L和8.42mU/g肌酐。丙二醛的第95个百分位数分别为1.6mU g/L和1.8mU g/g肌酐。IMPY和PNP的第95个百分位数分别为3.7mUg/L(3.4mug/g肌酐)和5.mg/L(4.2mug/g肌酐)。多因素分析显示，6-11岁儿童的TCPY浓度显著高于成人和青少年。同样，青少年的TCPY浓度明显高于成年人。虽然不同性别和混合种族/民族之间的集中度有所不同，但没有观察到显著差异。(C)2005 Elsevier Inc.保留所有权利。
We report population-based concentrations (stratified by age, sex, and composite race/ethnicity variables) of selective metabolites of chlorpyrifos (3,5,6-trichloro-2-pyridinol; TCPY), chlorpyrifos methyl (TCPY), malathion (malathion dicarboxylic acid; MDA), diazinon (2-isopropyl-4-methyl-6-hydroxypyrimidine; IMPY), methyl parathion (para-nitrophenol; PNP), and parathion (PNP). We measured the concentrations of TCPY, MDA, IMPY, and PNP in 1997 urine samples from participants, aged 6-59 years, of the National Health and Nutrition Examination Survey, 1999-2000. We detected TCPY in more than 96% of the samples tested. Other organophosphorus pesticide metabolites were detected less frequently: MDA, 52%; IMPY, 29%; and PNP, 22%. The geometric means for TCPY were 1.77 mu g/L and 1.58 mu g/g creatinine. The 95th percentiles for TCPY were 9.9 mu g/L and 8.42 mu/g creatinine. The 95th percentiles for MDA were 1.6 mu g/L and 1.8 mu g/g creatinine. The 95th percentiles for IMPY and PNP were 3.7 mu g/L (3.4 mu g/g creatinine) and 5.mu g/L (4.2 mu g/g creatinine), respectively. Multivariate analyses showed that children aged 6-11 years had significantly higher concentrations of TCPY than adults and adolescents. Similarly, adolescents had significantly higher TCPY concentrations than adults. Although the concentrations between sexes and among composite racial/ethnic groups varied, no significant differences were observed. (c) 2005 Elsevier Inc. All rights reserved.