Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain
Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain
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DOI：
10.1016/s0028-3908(00)00137-4
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发表时间：
2000-01-01
影响因子：
4.7
通讯作者：
Picciotto, MR
中科院分区：
文献类型：
--
作者：
Caldarone, BJ;Duman, CH;Picciotto, MR
尼古丁可以在几项认知测试中提高表现，但介导这些影响的特定尼古丁受体亚型在很大程度上尚不清楚。缺乏尼古丁受体Beta2亚基的敲除小鼠在恐惧条件反射和潜在抑制任务中进行评估，以开始确定哪些受体亚型介导尼古丁的认知效应。年轻的(2-4个月)敲除和野生型小鼠在情境或语气条件恐惧方面没有区别，但老年(9-20个月)的敲除雄性小鼠与年迈的野生型雄性小鼠相比，在对上下文和语气的冰冻方面都受到了损害。在老年敲除型和野生型雌性之间，没有观察到恐惧条件反射的差异。还评估了恐惧对预先暴露的语气的潜在抑制，通过行为冻结来衡量。基因敲除小鼠和野生型小鼠都表现出相似的潜在抑制水平，尽管基因敲除小鼠的整体冰冻水平较低。这些结果支持了先前的一项研究，该研究表明老年Beta2亚单位敲除小鼠存在空间学习缺陷[EMBO J.18(1999)1235]，并表明其他认知任务的表现可能不会因为缺乏含有Beta2亚单位的受体而受到影响。(C)2000爱思唯尔科学有限公司。保留所有权利。
Nicotine can enhance performance in several tests of cognition but the specific nicotinic receptor subtypes mediating these effects are largely unknown. Knock out mice lacking the beta2 subunit of the nicotinic receptor were evaluated in fear conditioning and latent inhibition tasks to begin to determine which receptor subtypes mediate the cognitive effects of nicotine. Young (2-4 months) knock out and wild type mice did not differ in either contextual or tone-conditioned fear, but aged (9-20 months) knock out males were impaired in freezing to both context and tone compared to aged wild type males. No differences in fear conditioning were observed between aged knock out and wild type females. Latent inhibition of fear to a pre-exposed tone, as measured by behavioral freezing, was also assessed. Both knock out and wild type mice displayed similar levels of latent inhibition, although overall levels of freezing were lower in knock out mice. These results support a previous study showing spatial learning deficits in aged beta2 subunit knock out mice [EMBO J. 18 (1999) 1235] and suggest that performance of other cognitive tasks may not be influenced by absence of beta2 subunit-containing receptors. (C) 2000 Elsevier Science Ltd. All rights reserved.