THE SEQUENTIAL IRRADIATION OF MAMMALIAN-CELLS WITH X-RAYS AND CHARGED-PARTICLES OF HIGH LET
THE SEQUENTIAL IRRADIATION OF MAMMALIAN-CELLS WITH X-RAYS AND CHARGED-PARTICLES OF HIGH LET
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DOI：
10.2307/3576024
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发表时间：
1983-01-01
影响因子：
3.4
通讯作者：
ROHRIG, N
中科院分区：
文献类型：
--
作者：
BIRD, RP;ZAIDER, M;ROHRIG, N
在s晚期同步的中国仓鼠V79[肺成纤维细胞]细胞被高let（线性能量转移）带电粒子或X射线照射，或依次暴露于单剂量带电粒子和分级剂量的X射线中。带电粒子辐照由氘核（LET, 50 keV/.mu）组成。m)或3He离子（96或160 keV/.mu.m）。连续照射后获得的生存数据显示，与暴露于低let辐射相比，存在协同效应。为了量化这种效应，定义了一个增强比。根据这一概念，目前的数据表明，随着初剂量LET的增加或剂量大小的增加，相互作用效应会增强。这些数据是根据最近的理论公式进行讨论的，该公式预测了两种辐射产生的亚致死损伤之间相互作用的协同作用。
Chinese hamster V79 [lung fibroblasts] cells, synchronized in late-S phase, were irradiated with high-LET [linear energy transfer] charged particles or X rays, or exposed sequentially to a single dose of charged particles followed by graded doses of X rays. The charged-particle irradiations consisted of deuterons (LET, 50 keV/.mu.m) or 3He ions (96 or 160 keV/.mu.m). The survival data obtained following the sequential irradiations show a synergistic effect compared with exposure to the low-LET radiation. An enhancement ratio is defined in order to quantify this effect. On the basis of this concept the present data show an enhanced interaction effect as the LET of the primary dose is increased or the size of this dose is increased. The data are discussed in terms of a recent theoretical formulation which predicts synergism as a result of the interaction between the sublethal damage produced by the 2 radiations.