Keeping development on time: Insights into post-transcriptional mechanisms driving oscillatory gene expression during vertebrate segmentation.
Keeping development on time: Insights into post-transcriptional mechanisms driving oscillatory gene expression during vertebrate segmentation.
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DOI：
10.1002/wrna.1751
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发表时间：
2023-01
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影响因子：
--
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中科院分区：
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生物计时，或生物过程发生的持续时间和节奏，是一种驱动动态分子和形态变化的现象，这些变化体现在生命的许多方面。在某些情况下，调节生物转变时间的分子机制是由遗传振荡或基因表达的周期性增加和减少驱动的，统称为“分子钟”。在脊椎动物中，分子钟在整个发育过程中的基本模式和细胞分化过程中发挥着至关重要的作用。例如，在早期脊椎动物胚胎发生过程中，分段时钟调节胚胎中胚层形成称为体节的分段组织块的模式，这些组织块随后产生轴向骨骼肌和椎骨。分段时钟振荡的特点是 mRNA 和蛋白质表达的快速周期。为了使分段时钟振荡持续存在，时钟基因的转录本和蛋白质分子必须是短暂的。忠实的、有节奏的遗传振荡是通过许多层面的精确调节（包括转录后调节）来维持的，这种机制对于脊椎动物的正常发育至关重要。 RNA 输出和定位 > RNA 定位 RNA 周转和监视 > RNA 稳定性翻译的调节 > 调节 本文分类如下：遗传振荡器在发育中发挥着至关重要的作用。分裂基因家族（Hes/her）的毛/增强子经历细胞自主遗传振荡来调节脊椎动物分割和神经细胞增殖和分化的时间。 mRNA 稳定性和翻译受到严格调节以维持振荡表达。
Biological time keeping, or the duration and tempo at which biological processes occur, is a phenomenon that drives dynamic molecular and morphological changes that manifest throughout many facets of life. In some cases, the molecular mechanisms regulating the timing of biological transitions are driven by genetic oscillations, or periodic increases and decreases in expression of genes described collectively as a “molecular clock.” In vertebrate animals, molecular clocks play a crucial role in fundamental patterning and cell differentiation processes throughout development. For example, during early vertebrate embryogenesis, the segmentation clock regulates the patterning of the embryonic mesoderm into segmented blocks of tissue called somites, which later give rise to axial skeletal muscle and vertebrae. Segmentation clock oscillations are characterized by rapid cycles of mRNA and protein expression. For segmentation clock oscillations to persist, the transcript and protein molecules of clock genes must be short‐lived. Faithful, rhythmic, genetic oscillations are sustained by precise regulation at many levels, including post‐transcriptional regulation, and such mechanisms are essential for proper vertebrate development. RNA Export and Localization > RNA Localization RNA Turnover and Surveillance > Regulation of RNA Stability Translation > Regulation This article is categorized under: Genetic oscillators play crucial roles in development. The hairy/Enhancer of split gene family (Hes/her) undergo cell‐autonomous genetic oscillations to regulate the timing of vertebrate segmentation and neural cell proliferation and differentiation. mRNA stability and translation are tightly regulated to maintain oscillatory expression.
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影响因子：
4.6
作者：
Ay, Ahmet;Holland, Jack;Oezbudak, Ertugrul M.
通讯作者：
Oezbudak, Ertugrul M.
影响因子：
14.9
作者：
Arvola, Rene M.;Chang, Chung-Te;Goldstrohm, Aaron C.
通讯作者：
Goldstrohm, Aaron C.
影响因子：
14.2
作者：
Casolaro, Vincenzo;Fang, Xi;Stellato, Cristiana
通讯作者：
Stellato, Cristiana
影响因子：
30.8
作者：
Bulman, MP;Kusumi, K;Turnpenny, PD
通讯作者：
Turnpenny, PD
DOI：
10.1073/pnas.95.5.2331
发表时间：
1998-03-03
影响因子：
11.1
作者：
Beck, ARP;Miller, IJ;Streuli, M
通讯作者：
Streuli, M