EVOKED BRAIN POTENTIALS AS INDICATORS OF DECISION-MAKING
EVOKED BRAIN POTENTIALS AS INDICATORS OF DECISION-MAKING
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DOI：
10.1126/science.1114321
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发表时间：
1975-01-01
期刊：
影响因子：
56.9
通讯作者：
PORJESZ, B
中科院分区：
文献类型：
--
作者：
BEGLEITER, H;PORJESZ, B
最近的研究表明，人类和猿类在唾液酸（Sia）生物学方面存在多种差异，包括Siglecs（Sia识别Ig超家族凝集素）。与黑猩猩基因组的比较表明，人类SIGLEC 11是通过相邻假基因的人类特异性基因转换而出现的。转换涉及5个非翻译序列和Sia识别结构域。这种人类蛋白质显示出相对于祖先形式减少的结合，但识别在大脑中富集的寡唾液酸。SIGLEC 11在人类但不在黑猩猩脑小胶质细胞中表达。进一步的研究将确定这一事件是否与人属的进化有关。
Recent studies have shown multiple differences between humans and apes in sialic acid (Sia) biology, including Siglecs (Sia-recognizing-Ig-superfamily lectins). Comparisons with the chimpanzee genome indicate that humanSIGLEC11emerged through human-specific gene conversion by an adjacent pseudogene. Conversion involved 5 untranslated sequences and the Sia-recognition domain. This human protein shows reduced binding relative to the ancestral form but recognizes oligosialic acids, which are enriched in the brain.SIGLEC11is expressed in human but not in chimpanzee brain microglia. Further studies will determine if this event was related to the evolution ofHomo.