ALE meta-analysis of action observation and imitation in the human brain.
ALE meta-analysis of action observation and imitation in the human brain.
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DOI：
10.1016/j.neuroimage.2009.12.112
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发表时间：
2010-04-15
期刊：
影响因子：
5.7
通讯作者：
Eickhoff SB
中科院分区：
文献类型：
--
作者：
Caspers S;Zilles K;Laird AR;Eickhoff SB
在过去的十年中，许多神经影像学研究已经评估了人类大脑网络的行动观察和模仿使用各种任务和范式。然而，关于哪些区域始终有助于这些网络，无论特定的实验设计，以及如何处理可能是偏侧化的问题仍然没有解决。目前的研究旨在确定皮层区域始终参与行动的观察和模仿相结合的激活似然估计（ALE）的荟萃分析与概率cytoarchitectonic地图。对139个功能性磁共振和正电子发射断层扫描实验的荟萃分析显示，行为观察和模仿都存在双边网络。对每个网络中不同效应物的额外子分析显示，与观察和模仿的整体分析分别具有高度可比性的激活模式，表明这些发现与潜在混淆无关。动作观察和模仿荟萃分析的连接分析显示，在额叶运动前区，顶叶和颞枕叶皮层的双边网络。最一致的吻侧下顶叶区是PFt，这为该区域与猕猴PF区可能的同源性提供了证据。观察和模仿网络特别是在涉及Broca区方面有所不同：尽管两个网络都涉及BA 44的尾背部分，但观察期间的激活在更吻背的位置最为一致，即，背侧BA 45，而在模仿过程中激活是最一致的，在一个更腹尾侧的方面，即，尾侧BA 44.因此，本元分析总结和修正了以前的描述有关的行动观察和模仿的人脑网络。
Over the last decade, many neuroimaging studies have assessed the human brain networks underlying action observation and imitation using a variety of tasks and paradigms. Nevertheless, questions concerning which areas consistently contribute to these networks irrespective of the particular experimental design and how such processing may be lateralized remain unresolved. The current study aimed at identifying cortical areas consistently involved in action observation and imitation by combining activation likelihood estimation (ALE) meta-analysis with probabilistic cytoarchitectonic maps. Meta-analysis of 139 functional magnetic resonance and positron emission tomography experiments revealed a bilateral network for both action observation and imitation. Additional subanalyses for different effectors within each network revealed highly comparable activation patterns to the overall analyses on observation and imitation, respectively, indicating an independence of these findings from potential confounds. Conjunction analysis of action observation and imitation meta-analyses revealed a bilateral network within frontal premotor, parietal, and temporo-occipital cortex. The most consistently rostral inferior parietal area was PFt, providing evidence for a possible homology of this region to macaque area PF. The observation and imitation networks differed particularly with respect to the involvement of Broca's area: whereas both networks involved a caudo-dorsal part of BA 44, activation during observation was most consistent in a more rostro-dorsal location, i.e., dorsal BA 45, while activation during imitation was most consistent in a more ventro-caudal aspect, i.e., caudal BA 44. The present meta-analysis thus summarizes and amends previous descriptions of the human brain networks related to action observation and imitation.