Passive cold devices for vaccine supply chains
Passive cold devices for vaccine supply chains
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DOI：
10.1007/s10479-013-1502-5
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发表时间：
2015-07-01
影响因子：
4.8
通讯作者：
Lee, Bruce Y.
中科院分区：
文献类型：
--
作者：
Chen, Sheng-I;Norman, Bryan A.;Lee, Bruce Y.
许多低收入和中等收入国家的一个主要优先事项是通过有效的疫苗接种计划根除传染病。然而，缺乏可靠的基础设施、设备和支助往往证明是这些国家的重大障碍。特别是，不可靠的电力和制冷设备是主要的问题，这促使研究开发不依赖于电力并且可以使用诸如冰的被动介质在延长的时间段内保持低温的被动冷藏装置（PCD）。PCD的发展还处于早期阶段，有许多悬而未决的问题，包括它们应该如何确定尺寸，价格和设备尺寸之间的相互作用，以及它们应该多久补充一次。到目前为止，这些类型的问题还没有被系统地分析的研究文献中的任何地方，本文描述了一个模型来解决这些问题，以更好地指导PCD在不久的将来的发展。本文使用来自一个代表性国家的真实的数据检查了实际用例，并提出了一个模型，该模型可以捕获在开发合适的PCD时必须考虑的各种权衡，同时提供关于什么是有用的、稳健的和经济的设计的指导。
A major priority in many low and middle income countries is the eradication of infectious diseases through an effective vaccination program. However, the lack of reliable infrastructure, equipment and support often prove to be significant barriers in such countries. In particular, unreliable electric power and refrigeration equipment are major concerns and this has prompted research into the development of passive cold storage devices (PCDs) that are not dependent on electric power and can maintain cold temperatures for extended periods of time using a passive medium such as ice. The development of PCDs is in its early stages, and there are many open questions including how they should be sized, the interaction between price and device size, and how often they should be replenished. So far, these types of questions have not been systematically analyzed anywhere in the research literature, and this paper describes a model to address these issues in order to better guide the development of PCDs in the near future. This paper examines actual use cases with real data from a representative country, and presents a model that captures the various tradeoffs that must be considered in developing a suitable PCD while providing guidance on what would constitute a useful, robust and economical design.