The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst
The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst
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黄体酮注射后子宫内膜厚度变化对单冻融囊胚移植患者妊娠结局的影响
DOI：
10.1186/s12958-019-0545-0
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发表时间：
2019-11-25
影响因子：
4.4
通讯作者：
Sun, Yingpu
中科院分区：
文献类型：
--
作者：
Bu, Zhiqin;Yang, Xinhong;Sun, Yingpu
BackgroundThe的目的是探讨孕激素给药后子宫内膜厚度变化对单个冻融胚泡移植患者妊娠结局的影响。MethodsThis观察性队列研究共纳入3091例患者，这些患者在2015年4月至2019年3月期间接受了首次冻融胚胎移植（FET）周期。子宫内膜厚度通过经阴道超声测量两次：在孕激素给药当天和胚胎移植当天。子宫内膜厚度的变化recorded. ResultsIndependently子宫内膜的准备协议（雌激素-孕激素/自然周期），女性年龄，体重指数（BMI），和不孕症的诊断是可比的子宫内膜增加的胚胎移植的一天，那些没有。临床妊娠率随子宫内膜厚度比值的增加而增加。移植当天子宫内膜增加者的临床妊娠率明显高于子宫内膜未增加者（雌孕激素周期为56.21%vs47.13%，P = 0.00; 55.15%vs49.55%，P = 0.00）。胚胎移植日（孕激素给药后）子宫内膜厚度较孕激素给药日增加或保持稳定。孕激素给药后子宫内膜增加与妊娠结局较好相关。
BackgroundThe aim of this study was to explore the impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst.MethodsThis observational cohort study included a total of 3091 patients undergoing their first frozen-thawed embryo transfer (FET) cycles between April 2015 to March 2019. Endometrial thickness was measured by trans-vaginal ultrasound twice for each patient: on day of progesterone administration, and on day of embryo transfer. The change of endometrial thickness was recorded.ResultsRegardless of endometrial preparation protocol (estrogen-progesterone/natural cycle), female age, body mass index (BMI), and infertility diagnosis were comparable between patients with an increasing endometrium on day of embryo transfer and those without. However, clinical pregnancy rate increases with increasing ratio of endometrial thickness. Compared with patients with Non-increase endometrium, those with an increasing endometrium on day of embryo transfer resulted in significantly higher clinical pregnancy rate (56.21% vs 47.13%,P= 0.00 in estrogen-progesterone cycle; 55.15% vs 49.55%,P= 0.00 in natural cycle).ConclusionsIn most patients, endometrial thickness on day of embryo transfer (after progesterone administration) increased or kept being stable compared with that on day of progesterone administration. An increased endometrium after progesterone administration was associated with better pregnancy outcome.