APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases.
APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases.
复制标题
DOI：
10.1371/journal.pone.0155072
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Murata M
中科院分区：
文献类型：
--
作者：
Midorikawa K;Soukaloun D;Akkhavong K;Southivong B;Rattanavong O;Sengkhygnavong V;Pyaluanglath A;Sayasithsena S;Nakamura S;Midorikawa Y;Murata M
年龄增长与非传染性疾病的风险增加有关，包括痴呆症和阿尔茨海默病（AD）。载脂蛋白E（APOE）ε4等位基因不仅是AD的危险因素，也是认知能力下降、抑郁症状、中风、高血压、冠心病、心血管疾病和糖尿病的危险因素。老挝人民民主共和国（老挝）正在发展;因此，预期寿命有所提高。为了评估未来非传染性疾病的风险，我们调查了老挝人群的APOE基因型和人体测量特征。受试者为455名老挝多数民族成员和354名少数民族成员。记录载脂蛋白E基因型、人体测量学特征、血压和血糖。为了比较个体变化，从老挝受试者的一个子集中获得了间隔5年收集的健康检查数据。APOE ε4等位基因频率在少数民族中（31.3%）高于老挝族（12.6%）。在老挝，各年龄组的平均腰围和血压显著增加，但少数民族没有。对五年期间开始和结束时的健康状况进行的比较显示，老挝的肥胖和血糖水平显著上升。APOE ε4携带者在两个种族组中均表现出静息心率显著增加。老挝少数民族ε4等位基因频率高于老挝多数民族。此外，在中年少数民族中观察到更高的肥胖、血压和血糖。因此，鉴于这些遗传和非传染性疾病的风险因素，随着老挝人口老龄化，痴呆症等与老龄化有关的非传染性疾病的发病率也可能会上升。
Increasing age is associated with elevated risk of non-communicable diseases, including dementia and Alzheimer’s disease (AD). The apolipoprotein E (APOE) ε4 allele is a risk factor not only for AD, but also for cognitive decline, depressive symptoms, stroke, hypertension, coronary heart disease, cardiovascular disease, and diabetes. The Lao People’s Democratic Republic (Laos) is undergoing development; consequently, life expectancy has risen. To evaluate the future risk of non-communicable diseases, we investigated APOE genotypes and anthropometric characteristics in the Laotian population. Subjects were 455 members of the Lao Loum majority and 354 members of ethnic minorities. APOE genotypes, anthropometric characteristics, blood pressure, and blood glucose were recorded. To compare individual changes, health examination data collected 5 years apart were obtained from a subset of Lao Loum subjects. APOE ε4 allele frequencies were higher among minorities (31.3%) than among Lao Loum (12.6%). In Lao Loum, but not in minorities, mean waist circumference and blood pressure increased significantly across age groups. Comparisons of health conditions between the beginning and end of the 5-year period revealed significant increases in obesity and blood glucose levels in Lao Loum. APOE ε4 carriers exhibited significant increases in resting heart rate in both ethnic groups. A higher ε4 allele frequency was observed in Laotian minorities than in the Laotian majority. Furthermore, higher obesity, blood pressure and blood glucose were observed in the middle-aged ethnic majority. Therefore, given these genetic and non-communicable disease risk factors, it seems likely that as the Laotian population ages, elevated rates of non-communicable aging-related diseases, such as dementia, will also become more prevalent.