Duodenal acidification: Role of first part of duodenum in gastric emptying and secretion in dogs.
Duodenal acidification: Role of first part of duodenum in gastric emptying and secretion in dogs.
复制标题
十二指肠酸化：十二指肠第一部分在狗胃排空和分泌中的作用。
DOI：
10.1016/s0016-5085(19)32928-2
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发表时间：
1974
期刊：
影响因子：
29.4
通讯作者：
A. R. Cooke
中科院分区：
文献类型：
--
作者：
A. R. Cooke
在有胃瘘和十二指肠瘘的狗身上研究了十二指肠酸化对胃排空和胃酸分泌的反应。十二指肠瘘放置在幽门（十二指肠第一部分）远端约5 cm处。在5只犬中进行了三个系列的排空研究。在一个系列中，研究了生理盐水餐（300 ml）的胃排空对以100 ml/hr的恒定速率灌注十二指肠的第二部分和远端的0、4、8、12和16 mEq/hr的量的HCl的响应。在第二个系列中，仅十二指肠的近端5cm被酸化，这是通过在十二指肠瘘处转移酸性试验餐（300 ml 40、80或120 mEq/L HCl）来完成的。在第三系列试验中，酸餐与酸灌注相结合，使整个十二指肠和近端空肠酸化。对照由盐水测试餐（300 ml）和十二指肠的盐水灌注组成。在十二指肠的第一部分中，酸的胃排空延迟，并且延迟大约等于十二指肠的其余部分的灌注。整个十二指肠的酸化造成最大的排空延迟，最大的效果是在响应于12毫当量每小时。延迟胃排空与酸在近端5厘米的十二指肠是快速和敏感的，并发生在1分钟内，并响应于0.24至0.36毫当量的盐酸。在3只狗中研究了让组胺和五肽胃泌素刺激的酸浸泡十二指肠第一部分（近端5 cm）的效果。这是通过关闭胃瘘和收集十二指肠瘘来完成的。结果发现，酸化的第一部分的十二指肠引起抑制（40%）五肽胃泌素，但不是组胺刺激的酸分泌。这些研究表明，十二指肠近端5 cm（第一部分）不仅对抑制胃酸分泌很重要，而且也是抑制胃排空的有效和敏感部位。
Gastric emptying and gastric acid secretion in response to duodenal acidification were studied in dogs with gastric and duodenal fistulae. The duodenal fistulae were placed about 5 cm distal to the pylorus (first part of the duodenum). Three series of emptying studies were done in 5 dogs. In one series, gastric emptying of a saline meal (300 ml) was studied in response to perfusion of the second part of the duodenum and distally with amounts of 0, 4, 8, 12, and 16 mEq per hr of HC1 at a constant rate of 100 ml per hr. In the second series, only the proximal 5 cm of the duodenum was acidified, and this was accomplished by diverting an acid test meal (300 ml of 40, 80, or 120 mEq per liter of HC1) at the duodenal fistula. In the third series of tests, the acid meals were combined with acid perfusion so that the whole duodenum and proximal jejunum was acidified. Controls consisted of saline test meals (300 ml) and saline perfusion of the duodenum. Gastric emptying with acid in the first part of the duodenum was delayed, and the delay was about equal to perfusion of the rest of the duodenum. Acidification of the whole duodenum caused greatest delay in emptying, and the maximal effect was in response to 12 mEq per hr. Delay in gastric emptying with acid in the proximal 5 cm of the duodenum was rapid and sensitive, and occurred within 1 min and in response to 0.24 to 0.36 mEq of HC1. The effect of allowing acid stimulated by histamine and pentagastrin to bathe the first part of the duodenum (proximal 5 cm) was studied in 3 dogs. This was done by closing the gastric fistula and collecting from the duodenal fistula. It was found that acidification of the first part of the duodenum caused inhibition (40%) of pentagastrin- but not histamine-stimulated acid secretion. These studies indicate that the proximal 5 cm of duodenum (first part) is not only important for inhibition of acid secretion, but is also a powerful and sensitive site for inhibition of gastric emptying.