Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction.
Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction.
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DOI：
10.1002/2211-5463.12226
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发表时间：
2017-06
期刊：
影响因子：
2.6
通讯作者：
Okada M
中科院分区：
文献类型：
--
作者：
Kuramoto K;Suzuki S;Sakaki H;Takeda H;Sanomachi T;Seino S;Narita Y;Kayama T;Kitanaka C;Okada M
多形性胶质母细胞瘤是恶性程度最高的原发性脑肿瘤。胶质瘤干细胞（GSCs）与常规治疗后的放化疗耐药和胶质母细胞瘤复发有关。GSCs的靶向治疗是胶质母细胞瘤患者长期生存的潜在有效治疗方法。甘草查尔酮A是一种来自甘草根的天然查尔酮，具有抗癌作用；然而，其对GSCs的影响尚不清楚。我们发现Licochalcone A在GSCs中诱导了大量caspase依赖性死亡，但在分化的GSCs和正常的体细胞和神经干细胞中没有引起死亡。在细胞死亡之前，Licochalcone A引起线粒体断裂，降低了GSCs的膜电位和ATP的产生。因此，Licochalcone A诱导线粒体功能障碍，有望成为抗癌干细胞药物。
Glioblastoma multiforme is the most malignant primary intrinsic brain tumor. Glioma stem cells (GSCs) are associated with chemoradiotherapy resistance and the recurrence of glioblastomas after conventional therapy. The targeting of GSCs is potentially an effective treatment for the long‐term survival of glioblastoma patients. Licochalcone A, a natural chalconoid from licorice root, exerts anticancer effects; however, its effect on GSCs remains unknown. We found that Licochalcone A induced massive caspase‐dependent death in GSCs but not in differentiated GSCs nor normal somatic and neural stem cells. Prior to cell death, Licochalcone A caused mitochondrial fragmentation and reduced the membrane potential and ATP production in GSCs. Thus, Licochalcone A induces mitochondrial dysfunction and shows promise as an anticancer stem cell drug.