Circular RNA has_circ_0003204 inhibits oxLDL-induced vascular endothelial cell proliferation and angiogenesis
Circular RNA has_circ_0003204 inhibits oxLDL-induced vascular endothelial cell proliferation and angiogenesis
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环状RNA has_circ_0003204抑制oxLDL诱导的血管内皮细胞增殖和血管生成
DOI：
10.1016/j.cellsig.2020.109595
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发表时间：
2020-06-01
影响因子：
4.8
通讯作者：
Chen, Fengling
中科院分区：
文献类型：
--
作者：
Liu, Huifang;Ma, Xirui;Chen, Fengling
环状RNA在真核细胞中广泛表达，在动脉粥样硬化中起关键作用。本研究旨在探讨hsA_CIRC_0003204与动脉粥样硬化的关系。HSA_CIRC_0003204在氧化型低密度脂蛋白诱导的人脐静脉内皮细胞中异常过表达。HSA_CIRC_0003204基因敲除可促进oxLDL诱导的人脐静脉内皮细胞的增殖、迁移和侵袭，但减少细胞的凋亡。此外，hSA_CIRC_0003204基因敲除可显著降低oxLDL诱导的人脐静脉内皮细胞E-钙粘附素的表达，增加N-钙粘附素和波形蛋白的表达。综上所述，这些发现提示hSA_CIRC_0003204在人脐静脉内皮细胞的增殖和血管生成中发挥重要作用，为治疗动脉粥样硬化中的内皮细胞损伤提供了一个潜在的靶点。
Circular RNAs (circRNAs) are widely expressed in eukaryotic cells and play a key role in atherosclerosis. The aim of this study is to explore the relationship between hsa_circ_0003204 and atherosclerosis. Here, hsa_circ_0003204 was aberrantly overexpressed in the ox-LDL-induced human umbilical vein endothelial cells (HUVECs). Knockdown of hsa_circ_0003204 facilitated the proliferation, migration, and invasion but reduced the apoptosis of oxLDL-induced HUVECs. Furthermore, hsa_circ_0003204 knockdown significantly reduced the E-cadherin expression but increased the expressions of N-cadherin and vimentin in oxLDL-induced HUVECs. Collectively, these findings suggest that hsa_circ_0003204 plays an important role in the proliferation and angiogenesis of HUVECs, providing a potential target for treating endothelial cell damage in atherosclerosis.