Transdermal delivery using a novel electrochemical device, part 1: device design and in vitro release/permeation of fentanyl.
Transdermal delivery using a novel electrochemical device, part 1: device design and in vitro release/permeation of fentanyl.
复制标题
使用新型电化学装置进行透皮递送，第 1 部分：装置设计和芬太尼的体外释放/渗透。
DOI：
10.1002/jps.22765
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发表时间：
2012
影响因子：
3.8
通讯作者：
Geoffrey Lee
中科院分区：
文献类型：
--
作者：
Britta Schröder;U. Nickel;E. Meyer;Geoffrey Lee
采用离体裸鼠皮肤释放/渗透实验研究了一种新型电化学透皮贴剂。贴片包括夹在平行于皮肤表面布置的两个电极之间的含药物水凝胶。目的是确定在施加低电压时，药物芬太尼的增强通量的工作机制。结果表明，电压诱导的水的水解存在于贴片的水凝胶发生。这导致pH变化，导致芬太尼的去质子化，从而增强释放/渗透。在20小时内，增强的通量高达约30 μg/（cm（2）h），并且仅需要在仅60 s的持续时间内施加低电压。由于增强机制发生在贴片中而不是皮肤中，因此与离子电渗疗法相比，可以大大减少皮肤刺激。
A new type of electrochemical transdermal patch has been investigated using release/permeation experiments with excised nude mouse skin. The patch comprises a drug-containing hydrogel sandwiched between two electrodes that are arranged parallel to the skin surface. The objective was to determine the mechanism of working of enhanced flux for the drug fentanyl when low voltages are applied. The results indicate that a voltage-induced hydrolysis of the water present in the patch's hydrogel occurs. This causes a pH shift that results in deprotonization of the fentanyl and hence enhanced release/permeation. The enhanced flux is up to approximately 30 μg/(cm(2) h) over 20 h and requires only a low-voltage application over a duration of just 60 s. Because the enhancement mechanism occurs in the patch and not in the skin, the potential for substantially reduced skin irritation compared with iontophoresis is given.