Diversin increases the proliferation and invasion ability of non-small-cell lung cancer cells via JNK pathway
Diversin increases the proliferation and invasion ability of non-small-cell lung cancer cells via JNK pathway
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Diversin通过JNK通路增加非小细胞肺癌细胞的增殖和侵袭能力
DOI：
10.1016/j.canlet.2013.10.033
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发表时间：
2014-03-28
期刊：
影响因子：
9.7
通讯作者：
Wang, Enhua
中科院分区：
文献类型：
--
作者：
Luan, Lan;Zhao, Yue;Wang, Enhua
Diversin在人类肿瘤中的表达和意义尚不清楚。我们发现Diversin在NSCLC中过表达，并与分化差、TNM分期、淋巴结转移和生存时间直接相关。Diversin的过表达可能通过激活JNK、cyclin B和MMP9导致NSCLC细胞的增殖和侵袭显著增加，而这种作用被JNK抑制剂阻断。这些结果提示Diversin在NSCLC中过表达，预示着不良预后。分化素可能通过JNK途径促进细胞增殖和侵袭。2013爱思唯尔爱尔兰有限公司版权所有。
The expression and significance of Diversin in human tumors remains unclear. We found that Diversin was overexpressed in NSCLC, and exhibited direct correlation to poor differentiation, advanced TNM stage, lymph node metastasis and survival time. Overexpression of Diversin lead to a significant increase in proliferation and invasion of NSCLC cells, possibly through activation of JNK, cyclin B and MMP9, and the effects were blocked by JNK inhibitor. These results suggest Diversin is overexpressed in NSCLC and predict poor prognosis. Diversin may promote cell proliferation and invasion through JNK pathway. (C) 2013 Elsevier Ireland Ltd. All rights reserved.