Microtubule-based force generation.
Microtubule-based force generation.
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DOI：
10.1002/wnan.1428
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Lele TP
中科院分区：
文献类型：
--
作者：
Kent IA;Lele TP
微管在许多重要的细胞过程中起着至关重要的作用，如细胞分裂、细胞货物运输、细胞器定位和细胞迁移。由于它们的功能不同，了解微管的功能是细胞生物学研究的重要组成部分，有助于对抗各种疾病。例如，微管是紫杉醇等化疗药物的重要靶点，因为它们在细胞分裂中起着关键作用。微管的许多功能与机械力的产生有关。这些力通常是微管聚合/解聚的直接结果，或者是由沿着微管连续移动的马达蛋白产生的。在这篇综述中，我们总结了最近在微管功能的背景下对微管产生的力进行量化和建模的努力。描述：微管以各种方式产生力量：聚合、解聚或与马达蛋白相互作用。
Microtubules are vital to many important cell processes, such as cell division, transport of cellular cargo, organelle positioning, and cell migration. Due to their diverse functions, understanding microtubule function is an important part of cell biological research that can help in combatting various diseases. For example, microtubules are an important target of chemotherapeutic drugs such as paclitaxel because of their pivotal role in cell division. Many functions of microtubules relate to the generation of mechanical forces. These forces are generally either a direct result of microtubule polymerization/depolymerization or generated by motor proteins that move processively along microtubules. In this review, we summarize recent efforts to quantify and model force generation by microtubules in the context of microtubule function. Caption: Microtubules produce force in various ways: by polymerization, depolymerisation, or interactions with motor proteins.