Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
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DOI：
10.1172/jci1594
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发表时间：
1998-04-15
影响因子：
15.9
通讯作者：
Makuuchi, M
中科院分区：
文献类型：
--
作者：
Abe, H;Yamada, N;Makuuchi, M
胰岛素抵抗常与肥胖和糖耐量受损的受试者的动脉粥样硬化性疾病有关。本研究在IRS-1缺陷小鼠（一种非肥胖的胰岛素抵抗动物模型）中检测了胰岛素抵抗对冠状动脉危险因素的影响。IRS-1缺陷小鼠的血压和血浆甘油三酯显著高于正常小鼠，在IRS-1缺陷小鼠中也观察到内皮依赖性血管舒张受损。此外，脂蛋白脂肪酶活性低于正常小鼠，表明在胰岛素抵抗条件下，脂解受损与血浆甘油三酯水平增加有关。胰岛素抵抗在冠状动脉危险因素的聚集中起重要作用，这可能加速具有胰岛素抵抗的受试者中动脉粥样硬化的进展。
Insulin resistance is often associated with atherosclerotic diseases in subjects with obesity and impaired glucose tolerance, This study examined the effects of insulin resistance on coronary risk factors in IRS-1 deficient mice, a nonobese animal model of insulin resistance, Blood pressure and plasma triglyceride let els were significantly higher in IRS-1 deficient mice than in normal mice, Impaired endothelium-dependent vascular relaxation was also observed in IRS-1 deficient mice, Furthermore, lipoprotein lipase activity was lower than in normal mice, suggesting impaired lipolysis to be involved in the increase in plasma triglyceride levels under insulin-resistant conditions, Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance.