Comparison of Behavioral Effects of Morphine and Fentanyl in Dogs and Cats
Comparison of Behavioral Effects of Morphine and Fentanyl in Dogs and Cats
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DOI：
10.1292/jvms.10-0565
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发表时间：
2012-02-01
影响因子：
1.2
通讯作者：
Nishimura, Ryohei
中科院分区：
文献类型：
--
作者：
Kamata, Masatoshi;Nagahama, Shotaro;Nishimura, Ryohei
观察静脉注射0.3、0.6、1.2、2.4 mU g/kg吗啡和5、10、20、40 mU g/kg芬太尼对犬、猫行为的影响。在狗身上，芬太尼和吗啡以剂量依赖的方式抑制活动和意识水平。在猫身上，较高剂量的芬太尼暂时刺激了活动，但没有观察到兴奋，即所谓的“阿片狂热”。吗啡引起明显的行为改变，特征是坐着盯着看，猫没有观察到“阿片狂热”。
Behavioral effects induced by intravenous administration of morphine at 0.3, 0.6, 1.2, and 2.4 mu g/kg and fentanyl at 5, 10, 20, and 40 mu g/kg were evaluated in dogs and cats. In dogs, fentanyl and morphine depressed activity and level of consciousness in a dose-dependant manner. In cats, higher doses of fentanyl stimulated activity temporarily, but excitement, so-called "opioid mania," was not observed. Morphine induced distinctive behavioral changes characterized by sitting with fixed staring, and "opioid mania" was not observed in cats.