Asymmetry in the human motor cortex and handedness
Asymmetry in the human motor cortex and handedness
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DOI：
10.1006/nimg.1996.0073
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发表时间：
1996-12-01
期刊：
影响因子：
5.7
通讯作者：
Zilles, K
中科院分区：
文献类型：
--
作者：
Amunts, K;Schlaug, G;Zilles, K
利手是最明显的功能不对称之一，但它与运动皮层中手代表区的解剖不对称的关系尚未得到证实。这将是一个关键的测试在皮层运动组织的结构功能相关性的假设。利用磁共振形态测量学，我们首次表明，中央沟的深度与惯用手。右撇子的左中央沟比右中央沟深，左撇子的左中央沟比右中央沟深。宏观结构不对称性由神经元体积中的微观结构左大于右的不对称性补充（即，包含树突、轴突和突触的组织隔室）。这些不对称性表明，手偏好与连接性增加（左4区神经元隔室增加）和优势半球中央前回的槽内表面增加有关。(C)出版社：Academic Press，Inc.
Handedness is one of the most obvious functional asymmetries, but its relation to an anatomical asymmetry of the hand representation area in the motor cortex has not been demonstrated. This would be a crucial test for the hypothesis of structure-function correlation in cortical motor organization. Using magnetic resonance morphometry, we show for the first time that the depth of the central sulcus is related to handedness. In right-handers, the left central sulcus is deeper than the right, and vice versa in left-handers. Macro-structural asymmetry is complemented by a microstructural left-larger-than-right asymmetry in neuropil volume (i.e., tissue compartment containing dendrites, axons, and synapses) in Brodmann's area 4. These asymmetries suggest that hand preference is associated with increased connectivity (demonstrated by an increased neuropil compartment in left area 4) and an increased intrasulcal surface of the precentral gyrus in the dominant hemisphere. (C) 1996 Academic Press, Inc.