Evidence for glial-mediated inflammation in aged APPSW transgenic mice
Evidence for glial-mediated inflammation in aged APPSW transgenic mice
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DOI：
10.1016/s0197-4580(99)00065-2
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发表时间：
1999-11-01
影响因子：
4.2
通讯作者：
Brunden, KR
中科院分区：
文献类型：
--
作者：
Benzing, WC;Wujek, JR;Brunden, KR
神经胶质细胞慢性表达炎症细胞因子，包括白介素1β、肿瘤坏死因子α和白介素6，可能是阿尔茨海默病(AD)患者脑内发生神经变性事件的基础。本研究确定了这些炎症标志物是否可以在Te(HuAPP695.K670N/M67 1L)2576转基因小鼠(Tg2576)的脑内观察到，这些转基因小鼠最近被证明模仿了AD的许多特征。白介素1β和特纳坏死因子α免疫阳性的小胶质细胞定位于硫代黄素阳性(纤维状)Aβ沉积。此外，白介素6免疫反应阳性的星形胶质细胞围绕纤维状Aβ沉积。这些发现提供了证据，证明Tg2516小鼠表现出AD所见的炎症病理特征，并表明这些小鼠是研究炎症在该疾病中可能扮演的角色的有用的动物模型。(C)2000 Elsevier Science Inc.保留所有权利。
Chronic expression of inflammatory cytokines, including interleukin-1 beta, tumor necrosis factor alpha, and interleukin-6, by glia may underlie the neurodegenerative events that occur within the brains of patients with Alzheimer's disease (AD). The present study determined whether these markers of inflammation could be observed within the brains of Te(HuAPP695.K670N/M67 1L)2576 transgenic mice (Tg2576) that have recently been shown to mimic many features of AD. Interleukin-1 beta- and turner necrosis factor alpha-immunopositive microglia were localized with thioflavine-positive (fibrillar) A beta deposits. Moreover, interleukin-6 immunoreactive astrocytes surrounded fibrillar A beta deposits. These findings provide evidence that Tg2516 mice exhibit features of the inflammatory pathology seen in AD and suggest that these mice are a useful animal model for studying the role inflammation may play in this disease. (C) 2000 Elsevier Science Inc. All rights reserved.