Cohesin's dual role in the DNA damage response: repair and checkpoint activation.
Cohesin's dual role in the DNA damage response: repair and checkpoint activation.
复制标题
粘蛋白在DNA损伤响应中的双重作用：修复和检查点激活。
DOI：
10.1038/emboj.2009.217
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发表时间：
2009-09-02
期刊：
影响因子：
11.4
通讯作者：
Jessberger, Rolf
中科院分区：
文献类型：
--
作者：
Jessberger, Rolf
使用内聚力使断裂的染色单体保持在其完整的姐妹染色单体附近，从而支持有效的修复，这是一个直截了当的概念。负责的蛋白质复合体粘附素在DNA损伤反应中至少还有一个额外的作用。正如沃特林和彼得斯在这一期中所展示的那样，G1、S内部和G2-MDNA损伤检查点需要的是凝聚素，而不是凝聚力。随着我们对粘附素及其相关复合体的不同功能和性质的了解的扩大，很明显，粘附素蛋白已经进化成几乎服务于与染色体有关的每一种基本反应。不足为奇的是，这些问题并没有减少。粘附素还有多少功能还会被描述，它们之间是如何联系的？在粘附素最初被描述为一种蛋白质复合体后，粘附素和相关复合体的其他作用被发现，包括DNA修复和重组、转录调节、可能是有丝分裂纺锤体的功能以及在减数分裂中的特定作用(有关综述，参见Strom和Sjogren，2007；Onn等，2008；Peters
Using cohesion to keep a broken chromatid in close proximity to its intact sister chromatid, thereby supporting efficient repair, is a straightforward concept. The responsible protein complex, cohesin, has at least one additional role in the DNA damage response. As Watrin and Peters show in this issue, cohesin, but not cohesion, is required for G1, intra-S and G2–M DNA damage checkpoints. As our knowledge of the distinct functions and properties of cohesin and related complexes expands, it becomes clear that cohesin proteins have evolved to serve in almost every fundamental reaction that concerns chromosomes. Not surprisingly, the questions do not become fewer.How many more functions of cohesin will still be described and how do they relate to each other? After the initial description of cohesin as a protein complex, which holds sister chromatids in cohesion, additional roles of cohesin and related complexes were discovered, including DNA repair and recombination, regulation of transcription, perhaps a function at the mitotic spindle, and specific roles in meiosis (for reviews, see Strom and Sjogren, 2007; Onn et al, 2008; Peters
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