Overweight, obesity and features of metabolic syndrome in children with diabetes treated with insulin pump therapy
Overweight, obesity and features of metabolic syndrome in children with diabetes treated with insulin pump therapy
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DOI：
10.1007/s00431-010-1372-7
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发表时间：
2011-07-01
影响因子：
3.6
通讯作者：
Bossowski, Artur
中科院分区：
文献类型：
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作者：
Luczynski, Wlodzimierz;Szypowska, Agnieszka;Bossowski, Artur
在接受持续皮下胰岛素输注（CSII）治疗的1型糖尿病（T1 DM）儿童中，尚未对致动脉粥样硬化风险因素进行具体评价。因此，我们研究了这些患者中超重/肥胖和代谢综合征的患病率。研究纳入了500例接受CSII和每日多次胰岛素（MDI）方案治疗的T1 DM儿童。在该组中评估人体测量数据/体格检查、糖尿病相关数据和血脂谱，并比较治疗方法（CSII vs. MDI）。近三分之一（30.2%）的儿童超重/肥胖。与诊断后3-6个月的BMI值相比，本评价时的体重指数（BMI）值显著较高。血脂异常占51.6%，高血压占4.8%，代谢综合征占3.2%。的主题。超重/肥胖儿童在代谢控制、高血压、血脂异常和代谢综合征的发生率方面与正常体重儿童不同。与男孩相比，女孩显示出更高的超重/肥胖患病率和更高的BMI值。与MDI方案治疗的儿童相比，CSII治疗的儿童超重/肥胖的患病率相同，但血脂异常的发生率较低，代谢控制较好。我们的研究显示，T1 DM儿童（包括接受胰岛素泵治疗的儿童）超重/肥胖和血脂异常的患病率较高。
There has been no specific evaluation of atherogenic risk factors in children with type 1 diabetes mellitus (T1DM) treated with continuous subcutaneous insulin infusion (CSII). We, therefore, studied the prevalence of overweight/obesity and metabolic syndrome among these patients. Five hundred children with T1DM treated with CSII and multiple daily insulin (MDI) regimen were included in the study. Anthropometric data/physical examination, data concerning diabetes, and a lipid profile were assessed in this group, and compared with respect to treatment method (CSII vs. MDI). Almost one-third (30.2%) of the children were overweight/obese. The body mass index (BMI) values at the time of the present evaluation were significantly higher in comparison with the BMI values 3-6 months after the diagnosis. Dyslipidemia was recognized in 51.6%, hypertension in 4.8%, and the metabolic syndrome in 3.2%. of the subjects. The overweight/obese children differed from their normal-weight counterparts with respect to metabolic control, the incidence of hypertension, dyslipidemia, and metabolic syndrome. The girls showed higher prevalence of overweight/obesity and higher BMI values compared to the boys. The children treated with CSII had the same prevalence of overweight/obesity, but a lower incidence of dyslipidemia, and a better metabolic control compared to the children treated with MDI regimen. Our study shows a high prevalence of overweight/obesity and dyslipidemia in children with T1DM including those treated with an insulin pump.